41335-62-0Relevant academic research and scientific papers
Discovery of cyclic sulfonamide derivatives as potent inhibitors of SARS-CoV-2
Shin, Young Sup,Lee, Jun Young,Noh, Soojin,Kwak, Yoonna,Jeon, Sangeun,Kwon, Sunoh,Jin, Young-hee,Jang, Min Seong,Kim, Seungtaek,Song, Jong Hwan,Kim, Hyoung Rae,Park, Chul Min
supporting information, (2020/11/13)
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) continues to spread worldwide, with 25 million confirmed cases and 800 thousand deaths. Effective treatments to target SARS-CoV-2 are urgently needed. In the present study, we have identified a
Synthesis and biological evaluation as well as in silico studies of arylpiperazine-1,2-benzothiazine derivatives as novel anti-inflammatory agents
Szcz??niak-Si?ga, Berenika M.,Wiatrak, Benita,Czy?nikowska, ?aneta,Janczak, Jan,Wiglusz, Rafal J.,Maniewska, Jadwiga
, (2020/12/02)
Novel arylpiperazine-1,2-benzothiazine derivatives have been designed and synthesized as potential anti-inflammatory agents. Their structure and properties have been studied using spectroscopic techniques (1H NMR, 13C NMR, FT-IR), MS
Synthesis of new tricyclic 1,2-thiazine derivatives with anti-inflammatory activity
Czy?nikowska, ?aneta,Maniewska, Jadwiga,Szcz??niak-Si?ga, Berenika M.,Wiatrak, Benita
, (2021/07/25)
New, tricyclic compounds containing a sulfonyl moiety in their structure, as potential safer COX inhibitors, were designed and synthesized. New derivatives have three conjugated rings and a sulfonyl group. A third ring, i.e., an oxazine, oxazepine or oxaz
Discovery of (2-benzoylethen-1-ol)-containing 1,2-benzothiazine derivatives as novel 4-hydroxyphenylpyruvate dioxygenase (HPPD) inhibiting-based herbicide lead compounds
Lei, Kang,Hua, Xue-Wen,Tao, Yuan-Yuan,Liu, Yang,Liu, Na,Ma, Yi,Li, Yong-Hong,Xu, Xiao-Hua,Kong, Chui-Hua
supporting information, p. 92 - 103 (2015/12/31)
A series of (2-benzoylethen-1-ol)-containing benzothiazine derivatives was synthesized, and their herbicidal activities were first evaluated. The bioassay results indicated that some of 3-benzoyl-4-hydroxy-2-methyl-2H-1,2-benzothiazine-1,1-dioxide derivatives displayed good herbicidal activity in greenhouse testing, especially, compound 4w had good pre-emergent herbicidal activities against Brassica campestris, Amaranthus retroflexus and Echinochloa crusgalli even at a dosage of 187.5 g ha-1. More importantly, compound 4w displayed significant inhibitory activity against Arabidopsis thaliana HPPD and was identified as the most potent candidate with IC50 value of 0.48 μM, which is better than the commercial herbicide sulctrione (IC50 = 0.53 μM) and comparable with the commercial herbicide mesotrione (IC50 = 0.25 μM). The structure-activity relationships was studied and provided some useful information for improving herbicidal activity. The present work indicated that (2-benzoylethen-1-ol)-containing 1,2-benzothiazine motif could be a potential lead structure for further development of novel HPPD inhibiting-based herbicides.
Saccharin-based μ-oxo imidoiodane: A readily available and highly reactive reagent for electrophilic amination
Yoshimura, Akira,Koski, Steven R.,Fuchs, Jonathan M.,Saito, Akio,Nemykin, Victor N.,Zhdankin, Viktor V.
supporting information, p. 5328 - 5331 (2015/03/30)
Three new saccharin-based hypervalent iodine compounds were prepared by the reaction of saccharine with (diacetoxyiodo)arenes or acetoxybenziodoxole. Structures of these new imidoiodanes were established by X-ray crystallography. The saccharin-based μ-oxo-bridged imidoiodane readily reacts with silyl enol ethers under mild conditions to give the corresponding α-aminated carbonyl compounds in moderate yields. Sweet saccharin: Three new saccharin-derived hypervalent iodine compounds were prepared by the reaction of saccharine with (diacetoxyiodo)arenes or acetoxybenziodoxole. The saccharin-based μ-oxo-bridged imidoiodane readily reacts with silyl enol ethers to give the corresponding α-aminated carbonyl compounds in moderate yields.
The interaction of new piroxicam analogues with lipid bilayers - A calorimetric and fluorescence spectroscopic study
Maniewska, Jadwiga,Szczesniak-Si Ga, Berenika,Pola, Andrzej,roda-Pomianek, Kamila,Malinka, Wieslaw,Michalak, Krystyna
, p. 1004 - 1012 (2015/02/02)
The purpose of the present paper was to assess the ability of new piroxicam analogues to interact with the lipid bilayers. The results of calorimetric and fluorescence spectroscopic experiments of two new synthesized analogues of piroxicam, named PR17 and
NBu4NI-Catalyzed oxidative imidation of ketones with imides: Synthesis of α-amino ketones
Lv, Yunhe,Li, Yan,Xiong, Tao,Lu, Yu,Liu, Qun,Zhang, Qian
supporting information, p. 2367 - 2369 (2014/03/21)
nBu4NI-Catalyzed oxidative imidation of ketones and imides for the synthesis of α-amino ketones were realized for the first time. The methodology is characterized by its wide substrate scope even for acetone with readily available phthalimide, saccharin and succinimide, which opens a new pathway for direct imidation of ketones. The Royal Society of Chemistry 2014.
Pyrazolo[4,3-c ][1,2]benzothiazines 5,5-dioxide: A promising new class of staphylococcus aureus NorA efflux pump inhibitors
Sabatini, Stefano,Gosetto, Francesca,Serritella, Serena,Manfroni, Giuseppe,Tabarrini, Oriana,Iraci, Nunzio,Brincat, Jean Pierre,Carosati, Emanuele,Villarini, Milena,Kaatz, Glenn W.,Cecchetti, Violetta
supporting information; experimental part, p. 3568 - 3572 (2012/06/17)
The increasing resistance to antibacterials commonly employed in the clinic and the growth of multidrug resistant strains suggest that the development of new therapeutic approaches should be of primary concern. In this context, EPIs may restore life to ol
