4-(4-chloro-phenyl)-5-(2,4,6-trifluoro-phenyl)-1,2-dihydropyridazine-3,6-dione

Base Information

Chemical Name:4-(4-chloro-phenyl)-5-(2,4,6-trifluoro-phenyl)-1,2-dihydropyridazine-3,6-dione
CAS No.:1041769-41-8
Molecular Formula:C₁₆H₈ClF₃N₂O₂
Molecular Weight:352.7
Hs Code.:

Synonyms:4-(4-chloro-phenyl)-5-(2,4,6-trifluoro-phenyl)-1,2-dihydropyridazine-3,6-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-chloro-phenyl)-5-(2,4,6-trifluoro-phenyl)-1,2-dihydropyridazine-3,6-dione

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Technology Process of 4-(4-chloro-phenyl)-5-(2,4,6-trifluoro-phenyl)-1,2-dihydropyridazine-3,6-dione

There total 2 articles about 4-(4-chloro-phenyl)-5-(2,4,6-trifluoro-phenyl)-1,2-dihydropyridazine-3,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1374964-01-8
3-(4-chloro-phenyl)-4-(2,4,6-trifluoro-phenyl)-furan-2,5-dione

: 1041769-41-8
4-(4-chloro-phenyl)-5-(2,4,6-trifluoro-phenyl)-1,2-dihydropyridazine-3,6-dione

Guidance literature:: With sodium acetate; hydrazine hydrate; acetic acid; In water; for 2h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmc.2012.03.035

Reference yield:

: 108-90-7
chlorobenzene

: 1041769-41-8
4-(4-chloro-phenyl)-5-(2,4,6-trifluoro-phenyl)-1,2-dihydropyridazine-3,6-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: aluminum (III) chloride / chloroform / 1 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: sodium hydroxide / 1,4-dioxane / 2 h / 20 °C / Inert atmosphere

2.2: pH 1

3.1: potassium tert-butylate / methanol / 1 h / 20 °C / Inert atmosphere

3.2: 3 h / 80 - 100 °C / Inert atmosphere

4.1: sodium acetate; hydrazine hydrate; acetic acid / water / 2 h / Inert atmosphere; Reflux

With aluminum (III) chloride; potassium tert-butylate; sodium acetate; hydrazine hydrate; acetic acid; sodium hydroxide; In 1,4-dioxane; methanol; chloroform; water; 1.1: Friedel-Crafts acylation / 1.2: Friedel-Crafts acylation / 3.2: Perkin type condensation;
DOI:10.1016/j.bmc.2012.03.035