3-chloro-5-(4-chloro-phenyl)-6-methoxy-4-(2,4,6-trifluoro-phenyl)-pyridazine

Base Information

Chemical Name:3-chloro-5-(4-chloro-phenyl)-6-methoxy-4-(2,4,6-trifluoro-phenyl)-pyridazine
CAS No.:1041769-95-2
Molecular Formula:C₁₇H₉Cl₂F₃N₂O
Molecular Weight:385.172
Hs Code.:

Synonyms:3-chloro-5-(4-chloro-phenyl)-6-methoxy-4-(2,4,6-trifluoro-phenyl)-pyridazine

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Chemical Property of 3-chloro-5-(4-chloro-phenyl)-6-methoxy-4-(2,4,6-trifluoro-phenyl)-pyridazine

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Technology Process of 3-chloro-5-(4-chloro-phenyl)-6-methoxy-4-(2,4,6-trifluoro-phenyl)-pyridazine

There total 5 articles about 3-chloro-5-(4-chloro-phenyl)-6-methoxy-4-(2,4,6-trifluoro-phenyl)-pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 67-56-1
methanol

: 1041769-43-0
3,6-dichloro-4-(4-chloro-phenyl)-5-(2,4,6-trifluoro-phenyl)-pyridazine

: 1041769-95-2
3-chloro-5-(4-chloro-phenyl)-6-methoxy-4-(2,4,6-trifluoro-phenyl)-pyridazine

Guidance literature:: With sodium methylate; for 2h; regioselective reaction; Inert atmosphere; Reflux;
DOI:10.1016/j.bmc.2012.03.035

Reference yield:

: 7099-88-9
4-chlorophenylglyoxylic acid

: 1041769-95-2
3-chloro-5-(4-chloro-phenyl)-6-methoxy-4-(2,4,6-trifluoro-phenyl)-pyridazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / methanol / 1 h / 20 °C / Inert atmosphere

1.2: 3 h / 80 - 100 °C / Inert atmosphere

2.1: sodium acetate; hydrazine hydrate; acetic acid / water / 2 h / Inert atmosphere; Reflux

3.1: trichlorophosphate / 2 h / 120 °C / Inert atmosphere

4.1: sodium methylate / 2 h / Inert atmosphere; Reflux

With potassium tert-butylate; sodium methylate; sodium acetate; hydrazine hydrate; acetic acid; trichlorophosphate; In methanol; water; 1.2: Perkin type condensation;
DOI:10.1016/j.bmc.2012.03.035

Reference yield:

: 1374964-01-8
3-(4-chloro-phenyl)-4-(2,4,6-trifluoro-phenyl)-furan-2,5-dione

: 1041769-95-2
3-chloro-5-(4-chloro-phenyl)-6-methoxy-4-(2,4,6-trifluoro-phenyl)-pyridazine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium acetate; hydrazine hydrate; acetic acid / water / 2 h / Inert atmosphere; Reflux

2: trichlorophosphate / 2 h / 120 °C / Inert atmosphere

3: sodium methylate / 2 h / Inert atmosphere; Reflux

With sodium methylate; sodium acetate; hydrazine hydrate; acetic acid; trichlorophosphate; In water;
DOI:10.1016/j.bmc.2012.03.035