3,6-dichloro-4-(4-chloro-phenyl)-5-(2,4,6-trifluoro-phenyl)-pyridazine

Base Information

Chemical Name:3,6-dichloro-4-(4-chloro-phenyl)-5-(2,4,6-trifluoro-phenyl)-pyridazine
CAS No.:1041769-43-0
Molecular Formula:C₁₆H₆Cl₃F₃N₂
Molecular Weight:389.591
Hs Code.:

Synonyms:3,6-dichloro-4-(4-chloro-phenyl)-5-(2,4,6-trifluoro-phenyl)-pyridazine

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Chemical Property of 3,6-dichloro-4-(4-chloro-phenyl)-5-(2,4,6-trifluoro-phenyl)-pyridazine

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Technology Process of 3,6-dichloro-4-(4-chloro-phenyl)-5-(2,4,6-trifluoro-phenyl)-pyridazine

There total 3 articles about 3,6-dichloro-4-(4-chloro-phenyl)-5-(2,4,6-trifluoro-phenyl)-pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 1041769-41-8
4-(4-chloro-phenyl)-5-(2,4,6-trifluoro-phenyl)-1,2-dihydropyridazine-3,6-dione

: 1041769-43-0
3,6-dichloro-4-(4-chloro-phenyl)-5-(2,4,6-trifluoro-phenyl)-pyridazine

Guidance literature:: With trichlorophosphate; at 120 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.03.035

Reference yield:

: 1374964-01-8
3-(4-chloro-phenyl)-4-(2,4,6-trifluoro-phenyl)-furan-2,5-dione

: 1041769-43-0
3,6-dichloro-4-(4-chloro-phenyl)-5-(2,4,6-trifluoro-phenyl)-pyridazine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium acetate; hydrazine hydrate; acetic acid / water / 2 h / Inert atmosphere; Reflux

2: trichlorophosphate / 2 h / 120 °C / Inert atmosphere

With sodium acetate; hydrazine hydrate; acetic acid; trichlorophosphate; In water;
DOI:10.1016/j.bmc.2012.03.035

Reference yield:

: 108-90-7
chlorobenzene

: 1041769-43-0
3,6-dichloro-4-(4-chloro-phenyl)-5-(2,4,6-trifluoro-phenyl)-pyridazine

Guidance literature:: Multi-step reaction with 5 steps

1.1: aluminum (III) chloride / chloroform / 1 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: sodium hydroxide / 1,4-dioxane / 2 h / 20 °C / Inert atmosphere

2.2: pH 1

3.1: potassium tert-butylate / methanol / 1 h / 20 °C / Inert atmosphere

3.2: 3 h / 80 - 100 °C / Inert atmosphere

4.1: sodium acetate; hydrazine hydrate; acetic acid / water / 2 h / Inert atmosphere; Reflux

5.1: trichlorophosphate / 2 h / 120 °C / Inert atmosphere

With aluminum (III) chloride; potassium tert-butylate; sodium acetate; hydrazine hydrate; acetic acid; sodium hydroxide; trichlorophosphate; In 1,4-dioxane; methanol; chloroform; water; 1.1: Friedel-Crafts acylation / 1.2: Friedel-Crafts acylation / 3.2: Perkin type condensation;
DOI:10.1016/j.bmc.2012.03.035