1-(4-(2-methylpyridin-4-yl)phenyl)-3-(8-phenyl-1,4-dioxaspiro[4.5]decan-8-yl)urea

Base Information

Chemical Name:1-(4-(2-methylpyridin-4-yl)phenyl)-3-(8-phenyl-1,4-dioxaspiro[4.5]decan-8-yl)urea
CAS No.:1195179-01-1
Molecular Formula:C₂₇H₂₉N₃O₃
Molecular Weight:443.546
Hs Code.:

Synonyms:1-(4-(2-methylpyridin-4-yl)phenyl)-3-(8-phenyl-1,4-dioxaspiro[4.5]decan-8-yl)urea

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Chemical Property of 1-(4-(2-methylpyridin-4-yl)phenyl)-3-(8-phenyl-1,4-dioxaspiro[4.5]decan-8-yl)urea

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Technology Process of 1-(4-(2-methylpyridin-4-yl)phenyl)-3-(8-phenyl-1,4-dioxaspiro[4.5]decan-8-yl)urea

There total 9 articles about 1-(4-(2-methylpyridin-4-yl)phenyl)-3-(8-phenyl-1,4-dioxaspiro[4.5]decan-8-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79741-43-8
8-phenyl-1,4-dioxaspiro[4.5]decan-8-amine

: 1195173-80-8
4-(2-methylpyridin-4-yl)benzoyl azide

: 1195179-01-1
1-(4-(2-methylpyridin-4-yl)phenyl)-3-(8-phenyl-1,4-dioxaspiro[4.5]decan-8-yl)urea

Guidance literature:: 4-(2-methylpyridin-4-yl)benzoyl azide; In tetrahydrofuran; at 120 ℃; for 0.25h; microwave irradiation;

8-phenyl-1,4-dioxaspiro[4.5]decan-8-amine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 22282-99-1
4-bromo-2-methylpyridine

: 1195179-01-1
1-(4-(2-methylpyridin-4-yl)phenyl)-3-(8-phenyl-1,4-dioxaspiro[4.5]decan-8-yl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / dihydrogen dichlorobis(di-tert-butylphosphinito-kP)palladate / 1,2-dimethoxyethane / 4 h / Reflux

2.1: hydrogenchloride; water / 11 h / 100 °C

3.1: triethylamine / tetrahydrofuran / 0.33 h / 0 °C

3.2: 0.5 h / 0 °C

3.3: 2 h / 0 - 20 °C

4.1: tetrahydrofuran / 0.25 h / 120 °C / microwave irradiation

4.2: 20 °C

With hydrogenchloride; water; caesium carbonate; triethylamine; dihydrogen dichlorobis(di-tert-butylphosphinito-kP)palladate; In tetrahydrofuran; 1,2-dimethoxyethane;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1195179-01-1
1-(4-(2-methylpyridin-4-yl)phenyl)-3-(8-phenyl-1,4-dioxaspiro[4.5]decan-8-yl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium phosphate / tetrahydrofuran / 0 - 20 °C / pH 6.9

2.1: sodium azide; trifluoroacetic acid / dichloromethane / 2 h / 0 °C

3.1: hydrogen / 10% Pd/C / ethanol / 20 °C

4.1: tetrahydrofuran / 0.25 h / 120 °C / microwave irradiation

4.2: 20 °C

With sodium azide; hydrogen; sodium phosphate; trifluoroacetic acid; 10% Pd/C; In tetrahydrofuran; ethanol; dichloromethane;