4-(4-Methoxy-phenyl)-2-oxo-6-phenyl-cyclohex-3-enecarboxylic acid (2-chloro-acetyl)-cyclohexyl-amide

Base Information

• Chemical Name: 4-(4-Methoxy-phenyl)-2-oxo-6-phenyl-cyclohex-3-enecarboxylic acid (2-chloro-acetyl)-cyclohexyl-amide
• CAS No.: 933769-97-2
• Molecular Formula: C₂₈H₃₀ClNO₄
• Molecular Weight: 480.003
• Mol file: 933769-97-2.mol

Synonyms:4-(4-Methoxy-phenyl)-2-oxo-6-phenyl-cyclohex-3-enecarboxylic acid (2-chloro-acetyl)-cyclohexyl-amide

Chemical Property of 4-(4-Methoxy-phenyl)-2-oxo-6-phenyl-cyclohex-3-enecarboxylic acid (2-chloro-acetyl)-cyclohexyl-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-Methoxy-phenyl)-2-oxo-6-phenyl-cyclohex-3-enecarboxylic acid (2-chloro-acetyl)-cyclohexyl-amide

There total 3 articles about 4-(4-Methoxy-phenyl)-2-oxo-6-phenyl-cyclohex-3-enecarboxylic acid (2-chloro-acetyl)-cyclohexyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

6-cyclohexylamido-3-p-methoxy-5-phenylcyclohex-2-enone (933769-91-6) + chloroacetyl chloride (79-04-9) → 4-(4-Methoxy-phenyl)-2-oxo-6-phenyl-cyclohex-3-enecarboxylic acid (2-chloro-acetyl)-cyclohexyl-amide (933769-97-2)

Guidance literature:

With pyridine; In chloroform; at 20 ℃; for 2h;

DOI:10.1080/10426500500366350

Reference yield:

ethyl 6-phenyl-4-(4-methoxyphenyl)-2-oxocyclohex-3-enecarboxylate (25960-25-2) → 4-(4-Methoxy-phenyl)-2-oxo-6-phenyl-cyclohex-3-enecarboxylic acid (2-chloro-acetyl)-cyclohexyl-amide (933769-97-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / Et₃N / p-xylene / 6 h / Heating

2: 62 percent / pyridine / CHCl₃ / 2 h / 20 °C

With pyridine; triethylamine; In chloroform; para-xylene;

DOI:10.1080/10426500500366350

Reference yield:

cyclohexylamine (108-91-8,157973-60-9) → 4-(4-Methoxy-phenyl)-2-oxo-6-phenyl-cyclohex-3-enecarboxylic acid (2-chloro-acetyl)-cyclohexyl-amide (933769-97-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / Et₃N / p-xylene / 6 h / Heating

2: 62 percent / pyridine / CHCl₃ / 2 h / 20 °C

With pyridine; triethylamine; In chloroform; para-xylene;

DOI:10.1080/10426500500366350

upstream raw materials:

6-cyclohexylamido-3-p-methoxy-5-phenylcyclohex-2-enone

chloroacetyl chloride

ethyl 6-phenyl-4-(4-methoxyphenyl)-2-oxocyclohex-3-enecarboxylate

cyclohexylamine