3-(chlorocarbonyl)-1,5-diphenyl-1H-pyrazole-4-carboxylic acid ethyl ester

Base Information

• Chemical Name: 3-(chlorocarbonyl)-1,5-diphenyl-1H-pyrazole-4-carboxylic acid ethyl ester
• CAS No.: 957470-78-9
• Molecular Formula: C₁₉H₁₅ClN₂O₃
• Molecular Weight: 354.793
• Mol file: 957470-78-9.mol

Synonyms:3-(chlorocarbonyl)-1,5-diphenyl-1H-pyrazole-4-carboxylic acid ethyl ester

Chemical Property of 3-(chlorocarbonyl)-1,5-diphenyl-1H-pyrazole-4-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-(chlorocarbonyl)-1,5-diphenyl-1H-pyrazole-4-carboxylic acid ethyl ester

There total 1 articles about 3-(chlorocarbonyl)-1,5-diphenyl-1H-pyrazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

4-(ethoxycarbonyl)-1,5-diphenyl-1H-pyrazole-3-carboxylic acid (872988-43-7) → 3-(chlorocarbonyl)-1,5-diphenyl-1H-pyrazole-4-carboxylic acid ethyl ester (957470-78-9)

Guidance literature:

With phosphorus pentachloride; In tetrachloromethane; for 3h; Heating;

DOI:10.1002/jhet.5570440516

Reference yield: 89.0%

3-(chlorocarbonyl)-1,5-diphenyl-1H-pyrazole-4-carboxylic acid ethyl ester (957470-78-9) + potassium thioacyanate (333-20-0) + sulfanilamide (63-74-1) → ethyl 1,5-diphenyl-3-(((4-sulfamoylphenyl)carbamothioyl)carbamoyl)-1H-pyrazole-4-carboxylate

Guidance literature:

3-(chlorocarbonyl)-1,5-diphenyl-1H-pyrazole-4-carboxylic acid ethyl ester; potassium thioacyanate; In acetone; for 0.5h; Reflux;

sulfanilamide; In acetone; for 2h; Reflux;

DOI:10.1016/j.molstruc.2019.127479

Reference yield: 85.0%

3-(chlorocarbonyl)-1,5-diphenyl-1H-pyrazole-4-carboxylic acid ethyl ester (957470-78-9) + Sulfathiazole (72-14-0) + potassium thioacyanate (333-20-0) → ethyl 1,5-diphenyl-3-(((4-(N-(thiazol-2-yl)sulfamoyl)phenyl)carbamothioyl) carbamoyl) -1H-pyrazole-4-carboxylate

Guidance literature:

3-(chlorocarbonyl)-1,5-diphenyl-1H-pyrazole-4-carboxylic acid ethyl ester; potassium thioacyanate; In acetone; for 0.5h; Reflux;

Sulfathiazole; In acetone; for 2h; Reflux;

DOI:10.1016/j.molstruc.2019.127479

upstream raw materials:

4-(ethoxycarbonyl)-1,5-diphenyl-1H-pyrazole-3-carboxylic acid

Downstream raw materials:

1,5-diphenyl-1H-pyrazole-3,4-dicarboxylic acid 4-ethyl-3-methyl ester

1,5-diphenyl-1H-pyrazole-3,4-dicarboxylic acid di-n-propyl ester

3-carbamoyl-1,5-diphenyl-1H-pyrazole-4-carboxylic acid ethyl ester

1,5-diphenyl-3-(3-phenylureidocarbonyl)-1H-pyrazole-4-carboxylic acid ethyl ester