C₈H₅BrClN

Base Information

• Chemical Name: C₈H₅BrClN
• CAS No.: 1202474-59-6
• Molecular Formula: C₈H₅BrClN
• Molecular Weight: 230.491
• Mol file: 1202474-59-6.mol

Synonyms:C₈H₅BrClN

Chemical Property of C₈H₅BrClN

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₈H₅BrClN

There total 3 articles about C₈H₅BrClN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-6-chloro-2-[2-(trimethylsilyl)ethynyl]aniline → C8H5BrClN (1202474-59-6)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1055/s-0035-1561305

Reference yield:

2-chloro-4-bromoaniline (38762-41-3) → C8H5BrClN (1202474-59-6)

Guidance literature:

Multi-step reaction with 3 steps

1: [bis(pyridine)iodine]⁺ tetrafluoroborate; tetrafluoroboric acid / dichloromethane / 20 °C

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 6 h / 20 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrafluoroboric acid; tetrabutyl ammonium fluoride; [bis(pyridine)iodine]⁺ tetrafluoroborate; triethylamine; In tetrahydrofuran; dichloromethane; 1: |Barluenga Lodination / 2: |Sonogashira Cross-Coupling;

DOI:10.1055/s-0035-1561305

Reference yield:

4-bromo-2-chloro-6-iodoaniline (56141-11-8) → C8H5BrClN (1202474-59-6)

Guidance literature:

Multi-step reaction with 2 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 6 h / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; 1: |Sonogashira Cross-Coupling;

DOI:10.1055/s-0035-1561305

upstream raw materials:

2-chloro-4-bromoaniline

4-bromo-2-chloro-6-iodoaniline

Downstream raw materials:

4-bromo-2-(6-bromo-8-chloro-4-methylquinolin-2-yl)-6-chlorophenylamine