4-(1-carboxy-1-methyl-ethoxy)-benzoic acid 4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl ester

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Chemical Name:4-(1-carboxy-1-methyl-ethoxy)-benzoic acid 4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl ester
CAS No.:1055303-58-6
Molecular Formula:C₂₃H₂₀F₃NO₅S
Molecular Weight:479.477
Hs Code.:

Synonyms:4-(1-carboxy-1-methyl-ethoxy)-benzoic acid 4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl ester

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Chemical Property of 4-(1-carboxy-1-methyl-ethoxy)-benzoic acid 4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl ester

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Technology Process of 4-(1-carboxy-1-methyl-ethoxy)-benzoic acid 4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl ester

There total 4 articles about 4-(1-carboxy-1-methyl-ethoxy)-benzoic acid 4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.4%

: 1055304-22-7
4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-benzoic acid 4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl ester

: 1055303-58-6
4-(1-carboxy-1-methyl-ethoxy)-benzoic acid 4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl ester

Guidance literature:: 4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-benzoic acid 4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 18h;

With water; sodium hydrogencarbonate; In diethyl ether; dichloromethane;

Reference yield:

: 1055304-21-6
4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-benzoic acid benzyl ester

: 1055303-58-6
4-(1-carboxy-1-methyl-ethoxy)-benzoic acid 4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 20 °C

2: caesium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.5 h / 50 °C

3: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With hydrogen; caesium carbonate; trifluoroacetic acid; potassium iodide; palladium 10% on activated carbon; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 94-18-8
Benzyl 4-hydroxybenzoate

: 1055303-58-6
4-(1-carboxy-1-methyl-ethoxy)-benzoic acid 4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / 19 h / 80 °C

2: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 20 °C

3: caesium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.5 h / 50 °C

4: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With hydrogen; sodium hydride; caesium carbonate; trifluoroacetic acid; potassium iodide; palladium 10% on activated carbon; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;