4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-benzoic acid benzyl ester

Base Information

• Chemical Name: 4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-benzoic acid benzyl ester
• CAS No.: 1055304-21-6
• Molecular Formula: C₂₂H₂₆O₅
• Molecular Weight: 370.445
• Mol file: 1055304-21-6.mol

Synonyms:4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-benzoic acid benzyl ester

Chemical Property of 4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-benzoic acid benzyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-benzoic acid benzyl ester

There total 1 articles about 4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-benzoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.8%

tert-butyl bromoisobutyrate (23877-12-5) + Benzyl 4-hydroxybenzoate (94-18-8) → 4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-benzoic acid benzyl ester (1055304-21-6)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 80 ℃; for 19h;

Reference yield: 96.1%

4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-benzoic acid benzyl ester (1055304-21-6) → 4-(1-tert-butoxy-2-methyl-1-oxopropan-2-yloxy)benzoic acid (950601-81-7)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethyl acetate; at 20 ℃; for 3h;

Reference yield:

4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-benzoic acid benzyl ester (1055304-21-6) → 4-(1-carboxy-1-methyl-ethoxy)-benzoic acid 4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl ester (1055303-58-6)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 20 °C

2: caesium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.5 h / 50 °C

3: trifluoroacetic acid / dichloromethane / 18 h / 20 °C

With hydrogen; caesium carbonate; trifluoroacetic acid; potassium iodide; palladium 10% on activated carbon; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

tert-butyl bromoisobutyrate

Benzyl 4-hydroxybenzoate

Downstream raw materials:

4-(1-tert-butoxy-2-methyl-1-oxopropan-2-yloxy)benzoic acid

4-(1-carboxy-1-methyl-ethoxy)-benzoic acid 4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl ester

4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-benzoic acid 4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl ester