4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-benzoic acid 4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl ester

Base Information

Chemical Name:4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-benzoic acid 4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl ester
CAS No.:1055304-22-7
Molecular Formula:C₂₇H₂₈F₃NO₅S
Molecular Weight:535.584
Hs Code.:

Synonyms:4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-benzoic acid 4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl ester

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Chemical Property of 4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-benzoic acid 4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl ester

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Technology Process of 4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-benzoic acid 4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl ester

There total 4 articles about 4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-benzoic acid 4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.8%

: 950601-81-7
4-(1-tert-butoxy-2-methyl-1-oxopropan-2-yloxy)benzoic acid

: 317318-97-1
5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole

: 1055304-22-7
4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-benzoic acid 4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl ester

Guidance literature:: With caesium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 50 ℃; for 0.5h;

Reference yield:

: 23877-12-5
tert-butyl bromoisobutyrate

: 1055304-22-7
4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-benzoic acid 4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide / 19 h / 80 °C

2: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 20 °C

3: caesium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.5 h / 50 °C

With hydrogen; sodium hydride; caesium carbonate; potassium iodide; palladium 10% on activated carbon; In ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1055304-21-6
4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-benzoic acid benzyl ester

: 1055304-22-7
4-(1-tert-butoxycarbonyl-1-methyl-ethoxy)-benzoic acid 4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 3 h / 20 °C

2: caesium carbonate; potassium iodide / N,N-dimethyl-formamide / 0.5 h / 50 °C

With hydrogen; caesium carbonate; potassium iodide; palladium 10% on activated carbon; In ethyl acetate; N,N-dimethyl-formamide;