diethyl methyl(5-methyl-4-{[(3R)-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-3-piperidinyl](2-propanyl)carbamoyl}-2-nitrophenoxy)propanedioate

Base Information

Chemical Name:diethyl methyl(5-methyl-4-{[(3R)-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-3-piperidinyl](2-propanyl)carbamoyl}-2-nitrophenoxy)propanedioate
CAS No.:1163283-26-8
Molecular Formula:C₂₉H₄₃N₃O₁₀
Molecular Weight:593.675
Hs Code.:

Synonyms:diethyl methyl(5-methyl-4-{[(3R)-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-3-piperidinyl](2-propanyl)carbamoyl}-2-nitrophenoxy)propanedioate

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Chemical Property of diethyl methyl(5-methyl-4-{[(3R)-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-3-piperidinyl](2-propanyl)carbamoyl}-2-nitrophenoxy)propanedioate

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Technology Process of diethyl methyl(5-methyl-4-{[(3R)-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-3-piperidinyl](2-propanyl)carbamoyl}-2-nitrophenoxy)propanedioate

There total 2 articles about diethyl methyl(5-methyl-4-{[(3R)-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-3-piperidinyl](2-propanyl)carbamoyl}-2-nitrophenoxy)propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 29263-94-3
diethyl bromomethylmalonate

: 1259436-25-3
2-methyl-2-propanyl (3R)-3-{[(4-hydroxy-2-methyl-5-nitrophenyl)carbonyl](2-propanyl)amino}-1-piperidinecarboxylate

: 1163283-26-8
diethyl methyl(5-methyl-4-{[(3R)-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-3-piperidinyl](2-propanyl)carbamoyl}-2-nitrophenoxy)propanedioate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 8h;

Reference yield:

: 1259436-23-1
2-Methyl-2-propanyl (3R)-3-[{[2-methyl-5-nitro-4-(2-propen-1-yloxy)phenyl]carbonyl}(2-propanyl)amino]-1-piperidinecarboxylate

: 1163283-26-8
diethyl methyl(5-methyl-4-{[(3R)-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-3-piperidinyl](2-propanyl)carbamoyl}-2-nitrophenoxy)propanedioate

Guidance literature:: Multi-step reaction with 2 steps

1: morpholine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 0.42 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C

With morpholine; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 1163283-26-8
diethyl methyl(5-methyl-4-{[(3R)-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-3-piperidinyl](2-propanyl)carbamoyl}-2-nitrophenoxy)propanedioate

: 1259436-27-5
2-Methyl-2-propanyl (3R)-3-[({4-[2-(dibenzylamino)ethyl]2-(methoxymethyl)-2,7-dimethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-6-yl}carbonyl)(2-propanyl)amino]-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid; iron / 10 h / 90 °C

2.1: potassium carbonate; 18-crown-6 ether / acetonitrile / 8 h / 80 °C

3.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 5 h / 60 °C

3.2: 20 °C

4.1: triethylamine / tetrahydrofuran / 1 h / Inert atmosphere; Cooling with ice

4.2: 1 h / Cooling with ice

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2.5 h / 20 °C / Cooling with ice

With 18-crown-6 ether; lithium hydroxide monohydrate; water; iron; sodium hydride; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; mineral oil;