(R)-2-(3-carbamoyl-2,4-difluorophenoxy)-3-hydroxypropionic acid 2-oxo-2-(4-trifluoromethylphenyl)ethyl ester

Base Information

Chemical Name:(R)-2-(3-carbamoyl-2,4-difluorophenoxy)-3-hydroxypropionic acid 2-oxo-2-(4-trifluoromethylphenyl)ethyl ester
CAS No.:1403884-05-8
Molecular Formula:C₁₉H₁₄F₅NO₆
Molecular Weight:447.315
Hs Code.:

Synonyms:(R)-2-(3-carbamoyl-2,4-difluorophenoxy)-3-hydroxypropionic acid 2-oxo-2-(4-trifluoromethylphenyl)ethyl ester

Suppliers and Price of (R)-2-(3-carbamoyl-2,4-difluorophenoxy)-3-hydroxypropionic acid 2-oxo-2-(4-trifluoromethylphenyl)ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-2-(3-carbamoyl-2,4-difluorophenoxy)-3-hydroxypropionic acid 2-oxo-2-(4-trifluoromethylphenyl)ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-2-(3-carbamoyl-2,4-difluorophenoxy)-3-hydroxypropionic acid 2-oxo-2-(4-trifluoromethylphenyl)ethyl ester

There total 3 articles about (R)-2-(3-carbamoyl-2,4-difluorophenoxy)-3-hydroxypropionic acid 2-oxo-2-(4-trifluoromethylphenyl)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1403884-04-7
cesium (R)-2-(3-carbamoyl-2,4-difluorophenoxy)-3-hydroxy-propionate

: 383-53-9
2-bromo-1-[4-(trifluoromethyl)phenyl]ethanone

: 1403884-05-8
(R)-2-(3-carbamoyl-2,4-difluorophenoxy)-3-hydroxypropionic acid 2-oxo-2-(4-trifluoromethylphenyl)ethyl ester

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 2,6-difluoro-3-methoxybenzamide

: 1403884-05-8
(R)-2-(3-carbamoyl-2,4-difluorophenoxy)-3-hydroxypropionic acid 2-oxo-2-(4-trifluoromethylphenyl)ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: boron tribromide / dichloromethane / 48 h / 20 °C / Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate; triethylamine / tetrahydrofuran / 48 h / 0 - 20 °C

3: 10 wt% Pd(OH)2 on carbon; hydrogen / tetrahydrofuran / 1 h / 20 °C / 760.05 Torr

4: water; caesium carbonate / acetonitrile / 4 h / 55 °C

5: N,N-dimethyl-formamide / 1 h / 20 °C

With 10 wt% Pd(OH)2 on carbon; water; hydrogen; boron tribromide; caesium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 2: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2013.11.002

Reference yield:

: 951122-37-5
2,6-difluoro-3-hydroxy-benzamide

: 1403884-05-8
(R)-2-(3-carbamoyl-2,4-difluorophenoxy)-3-hydroxypropionic acid 2-oxo-2-(4-trifluoromethylphenyl)ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; diethylazodicarboxylate; triethylamine / tetrahydrofuran / 48 h / 0 - 20 °C

2: 10 wt% Pd(OH)2 on carbon; hydrogen / tetrahydrofuran / 1 h / 20 °C / 760.05 Torr

3: water; caesium carbonate / acetonitrile / 4 h / 55 °C

4: N,N-dimethyl-formamide / 1 h / 20 °C

With 10 wt% Pd(OH)2 on carbon; water; hydrogen; caesium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 1: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2013.11.002