2,6-difluoro-3-{(R)-2-hydroxy-1-[4-(4-trifluoromethylphenyl)oxazol-2-yl]ethoxy}benzamide

Base Information

Chemical Name:2,6-difluoro-3-{(R)-2-hydroxy-1-[4-(4-trifluoromethylphenyl)oxazol-2-yl]ethoxy}benzamide
CAS No.:1403883-53-3
Molecular Formula:C₁₉H₁₃F₅N₂O₄
Molecular Weight:428.315
Hs Code.:

Synonyms:2,6-difluoro-3-{(R)-2-hydroxy-1-[4-(4-trifluoromethylphenyl)oxazol-2-yl]ethoxy}benzamide

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Chemical Property of 2,6-difluoro-3-{(R)-2-hydroxy-1-[4-(4-trifluoromethylphenyl)oxazol-2-yl]ethoxy}benzamide

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Technology Process of 2,6-difluoro-3-{(R)-2-hydroxy-1-[4-(4-trifluoromethylphenyl)oxazol-2-yl]ethoxy}benzamide

There total 6 articles about 2,6-difluoro-3-{(R)-2-hydroxy-1-[4-(4-trifluoromethylphenyl)oxazol-2-yl]ethoxy}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1403884-05-8
(R)-2-(3-carbamoyl-2,4-difluorophenoxy)-3-hydroxypropionic acid 2-oxo-2-(4-trifluoromethylphenyl)ethyl ester

: 1403883-53-3
2,6-difluoro-3-{(R)-2-hydroxy-1-[4-(4-trifluoromethylphenyl)oxazol-2-yl]ethoxy}benzamide

Guidance literature:: With acetamide; boron trifluoride diethyl etherate; In xylenes; for 2h; Reflux;

Reference yield:

: 1403884-04-7
cesium (R)-2-(3-carbamoyl-2,4-difluorophenoxy)-3-hydroxy-propionate

: 1403883-53-3
2,6-difluoro-3-{(R)-2-hydroxy-1-[4-(4-trifluoromethylphenyl)oxazol-2-yl]ethoxy}benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 1 h / 20 °C

2: boron trifluoride diethyl etherate; acetamide / xylenes / 2 h / Reflux

With acetamide; boron trifluoride diethyl etherate; In N,N-dimethyl-formamide; xylenes;

Reference yield:

: 2,6-difluoro-3-methoxybenzamide

: 1403883-53-3
2,6-difluoro-3-{(R)-2-hydroxy-1-[4-(4-trifluoromethylphenyl)oxazol-2-yl]ethoxy}benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: boron tribromide / dichloromethane / 48 h / 20 °C / Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate; triethylamine / tetrahydrofuran / 48 h / 0 - 20 °C

3: 10 wt% Pd(OH)2 on carbon; hydrogen / tetrahydrofuran / 1 h / 20 °C / 760.05 Torr

4: water; caesium carbonate / acetonitrile / 4 h / 55 °C

5: N,N-dimethyl-formamide / 1 h / 20 °C

6: boron trifluoride diethyl etherate; acetamide / 5,5-dimethyl-1,3-cyclohexadiene / 2 h / Reflux

With acetamide; 10 wt% Pd(OH)2 on carbon; boron trifluoride diethyl etherate; water; hydrogen; boron tribromide; caesium carbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 2: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2013.11.002