8-benzyl-2-exo-<(trimethylsilyl)oxy>-8-azabicyclo<3.2.1>octane-6-exo-carbonitrile

Base Information

Chemical Name:8-benzyl-2-exo-<(trimethylsilyl)oxy>-8-azabicyclo<3.2.1>octane-6-exo-carbonitrile
CAS No.:141557-07-5
Molecular Formula:C₁₈H₂₆N₂OSi
Molecular Weight:314.503
Hs Code.:

Synonyms:8-benzyl-2-exo-<(trimethylsilyl)oxy>-8-azabicyclo<3.2.1>octane-6-exo-carbonitrile

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Chemical Property of 8-benzyl-2-exo-<(trimethylsilyl)oxy>-8-azabicyclo<3.2.1>octane-6-exo-carbonitrile

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Technology Process of 8-benzyl-2-exo-<(trimethylsilyl)oxy>-8-azabicyclo<3.2.1>octane-6-exo-carbonitrile

There total 6 articles about 8-benzyl-2-exo-<(trimethylsilyl)oxy>-8-azabicyclo<3.2.1>octane-6-exo-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 75-77-4
chloro-trimethyl-silane

: 141557-06-4,141611-19-0
8-benzyl-2-exo-hydroxy-8-azabicyclo<3.2.1>octane-6-exo-carbonitrile

: 141557-07-5
8-benzyl-2-exo-<(trimethylsilyl)oxy>-8-azabicyclo<3.2.1>octane-6-exo-carbonitrile

Guidance literature:: With triethylamine; In diethyl ether; at 25 ℃; for 5h;
DOI:10.1021/jo00039a005

Reference yield:

: 62215-46-7,62215-47-8,141583-52-0,141583-53-1
8-benzyl-2-oxo-8-azabicyclo<3.2.1>oct-3-ene-6-exo-carbonitrile

: 141557-07-5
8-benzyl-2-exo-<(trimethylsilyl)oxy>-8-azabicyclo<3.2.1>octane-6-exo-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / hydrogen / black palladium / methanol / 5 h / Ambient temperature

2: 39 percent / sodium borohydride / methanol / 3 h / Ambient temperature

3: 84 percent / triethylamine / diethyl ether / 4 h / 25 °C

With sodium tetrahydroborate; hydrogen; triethylamine; palladium; In methanol; diethyl ether;
DOI:10.3987/com-98-8447

Reference yield:

: 109-00-2
3-HYDROXYPYRIDINE

: 141557-07-5
8-benzyl-2-exo-<(trimethylsilyl)oxy>-8-azabicyclo<3.2.1>octane-6-exo-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / acetone / Ambient temperature

2: 54.4 percent / Et₃N, hydroquinone / 20 h / Heating

3: 97 percent / H₂ / Pd-black / methanol / 20 h / 760 Torr / Ambient temperature

4: 56 percent / NaBH₄ / methanol / 2 h / 25 °C

5: 100 percent / Et₃N / diethyl ether / 5 h / 25 °C

With sodium tetrahydroborate; hydrogen; triethylamine; hydroquinone; palladium; In methanol; diethyl ether; acetone;
DOI:10.1021/jo00039a005