[2-[(4R,6R)-6-(p-methoxybenzyloxymethyl)-2,2-dimethyl[1,3]dioxan-4-yl]ethoxy]triisopropylsilane

Base Information

Chemical Name:[2-[(4R,6R)-6-(p-methoxybenzyloxymethyl)-2,2-dimethyl[1,3]dioxan-4-yl]ethoxy]triisopropylsilane
CAS No.:638222-30-7
Molecular Formula:C₂₆H₄₆O₅Si
Molecular Weight:466.734
Hs Code.:

Synonyms:[2-[(4R,6R)-6-(p-methoxybenzyloxymethyl)-2,2-dimethyl[1,3]dioxan-4-yl]ethoxy]triisopropylsilane

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Chemical Property of [2-[(4R,6R)-6-(p-methoxybenzyloxymethyl)-2,2-dimethyl[1,3]dioxan-4-yl]ethoxy]triisopropylsilane

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Technology Process of [2-[(4R,6R)-6-(p-methoxybenzyloxymethyl)-2,2-dimethyl[1,3]dioxan-4-yl]ethoxy]triisopropylsilane

There total 6 articles about [2-[(4R,6R)-6-(p-methoxybenzyloxymethyl)-2,2-dimethyl[1,3]dioxan-4-yl]ethoxy]triisopropylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 77-76-9
2,2-dimethoxy-propane

: 638222-37-4
(2R,4R)-1-(p-methoxybenzyloxy)-6-(triisopropylsilanyloxy)hexane-2,4-diol

: 638222-30-7
[2-[(4R,6R)-6-(p-methoxybenzyloxymethyl)-2,2-dimethyl[1,3]dioxan-4-yl]ethoxy]triisopropylsilane

Guidance literature:: With toluene-4-sulfonic acid; In acetone; at 0 ℃; for 1h;
DOI:10.1021/ol035848h

Reference yield:

: 80910-01-6,108836-41-5,144069-33-0,134733-19-0
(R)-2-(((4-methoxybenzyl)oxy)methyl)oxirane

: 638222-30-7
[2-[(4R,6R)-6-(p-methoxybenzyloxymethyl)-2,2-dimethyl[1,3]dioxan-4-yl]ethoxy]triisopropylsilane

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; heptane / 0.25 h / 20 °C

1.2: 98 percent / tetrahydrofuran; heptane / 1 h / -10 °C

2.1: 96 percent / iodine; aqueous sodium hydrogen carbonate / acetonitrile / 1 h / 0 °C

3.1: 94 percent / diethylmethoxyborane; sodium borohydride / tetrahydrofuran; methanol / -78 °C

4.1: 99 percent / para-toluenesulfonic acid monohydrate / acetone / 1 h / 0 °C

With sodium tetrahydroborate; n-butyllithium; diethyl methoxy borane; iodine; sodium hydrogencarbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; n-heptane; acetone; acetonitrile;
DOI:10.1021/ol035848h

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 638222-30-7
[2-[(4R,6R)-6-(p-methoxybenzyloxymethyl)-2,2-dimethyl[1,3]dioxan-4-yl]ethoxy]triisopropylsilane

Guidance literature:: Multi-step reaction with 5 steps

1.1: 75 percent / sodium hydride; tetra-n-butylammonium iodide / tetrahydrofuran / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; heptane / 0.25 h / 20 °C

2.2: 98 percent / tetrahydrofuran; heptane / 1 h / -10 °C

3.1: 96 percent / iodine; aqueous sodium hydrogen carbonate / acetonitrile / 1 h / 0 °C

4.1: 94 percent / diethylmethoxyborane; sodium borohydride / tetrahydrofuran; methanol / -78 °C

5.1: 99 percent / para-toluenesulfonic acid monohydrate / acetone / 1 h / 0 °C

With sodium tetrahydroborate; n-butyllithium; diethyl methoxy borane; iodine; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium hydrogencarbonate; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; n-heptane; acetone; acetonitrile;
DOI:10.1021/ol035848h