phenyl N-[4-[4-(1-cyclopropylsulfonylcyclopropyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]carbamate

Base Information

Chemical Name:phenyl N-[4-[4-(1-cyclopropylsulfonylcyclopropyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]carbamate
CAS No.:1101817-61-1
Molecular Formula:C₂₈H₃₀N₄O₅S
Molecular Weight:534.636
Hs Code.:

Synonyms:phenyl N-[4-[4-(1-cyclopropylsulfonylcyclopropyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]carbamate

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Chemical Property of phenyl N-[4-[4-(1-cyclopropylsulfonylcyclopropyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]carbamate

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Technology Process of phenyl N-[4-[4-(1-cyclopropylsulfonylcyclopropyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]carbamate

There total 9 articles about phenyl N-[4-[4-(1-cyclopropylsulfonylcyclopropyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1101817-62-2
4-[4-(1-cyclopropylsulfonylcyclopropyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]aniline

: 1885-14-9
phenyl chloroformate

: 1101817-61-1
phenyl N-[4-[4-(1-cyclopropylsulfonylcyclopropyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]carbamate

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield:

: 350595-57-2
(S)-3-methylmorpholine

: 1101817-61-1
phenyl N-[4-[4-(1-cyclopropylsulfonylcyclopropyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]carbamate

Guidance literature:: Multi-step reaction with 8 steps

1: triethylamine / dichloromethane / 1 h / 20 °C

2: lithium borohydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0.75 h / 0 - 20 °C / Inert atmosphere

4: sodium iodide / 20 h / 50 °C

5: acetonitrile / 3 h / 90 °C

6: tetrabutylammomium bromide; sodium hydroxide / water / 4 h / 60 - 70 °C

7: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; N,N-dimethyl-formamide; ethanol; 1,2-dimethoxyethane / 5 h / 80 - 95 °C / Inert atmosphere

8: sodium carbonate / 1,4-dioxane / 2 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; lithium borohydride; tetrabutylammomium bromide; sodium carbonate; triethylamine; sodium iodide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm501778s

Reference yield:

: 1009628-23-2
(S)-(2-chloro-6-(3-methylmorpholino)pyrimidin-4-yl)methyl methanesulfonate

: 1101817-61-1
phenyl N-[4-[4-(1-cyclopropylsulfonylcyclopropyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium iodide / 20 h / 50 °C

2: acetonitrile / 3 h / 90 °C

3: tetrabutylammomium bromide; sodium hydroxide / water / 4 h / 60 - 70 °C

4: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; N,N-dimethyl-formamide; ethanol; 1,2-dimethoxyethane / 5 h / 80 - 95 °C / Inert atmosphere

5: sodium carbonate / 1,4-dioxane / 2 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; tetrabutylammomium bromide; sodium carbonate; sodium iodide; sodium hydroxide; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm501778s