3-cyclopropyl-1-[4-[4-(1-cyclopropylsulfonylcyclopropyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]urea

Base Information

Chemical Name:3-cyclopropyl-1-[4-[4-(1-cyclopropylsulfonylcyclopropyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]urea
CAS No.:1101800-09-2
Molecular Formula:C₂₅H₃₁N₅O₄S
Molecular Weight:497.618
Hs Code.:

Synonyms:3-cyclopropyl-1-[4-[4-(1-cyclopropylsulfonylcyclopropyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]urea

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Chemical Property of 3-cyclopropyl-1-[4-[4-(1-cyclopropylsulfonylcyclopropyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]urea

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Technology Process of 3-cyclopropyl-1-[4-[4-(1-cyclopropylsulfonylcyclopropyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]urea

There total 10 articles about 3-cyclopropyl-1-[4-[4-(1-cyclopropylsulfonylcyclopropyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1101817-61-1
phenyl N-[4-[4-(1-cyclopropylsulfonylcyclopropyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]carbamate

: 765-30-0
Cyclopropylamine

: 1101800-09-2
3-cyclopropyl-1-[4-[4-(1-cyclopropylsulfonylcyclopropyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]urea

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 50 ℃; for 2h; Product distribution / selectivity;

Reference yield:

: 350595-57-2
(S)-3-methylmorpholine

: 1101800-09-2
3-cyclopropyl-1-[4-[4-(1-cyclopropylsulfonylcyclopropyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]urea

Guidance literature:: Multi-step reaction with 9 steps

1: triethylamine / dichloromethane / 1 h / 20 °C

2: lithium borohydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 0.75 h / 0 - 20 °C / Inert atmosphere

4: sodium iodide / 20 h / 50 °C

5: acetonitrile / 3 h / 90 °C

6: tetrabutylammomium bromide; sodium hydroxide / water / 4 h / 60 - 70 °C

7: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; N,N-dimethyl-formamide; ethanol; 1,2-dimethoxyethane / 5 h / 80 - 95 °C / Inert atmosphere

8: sodium carbonate / 1,4-dioxane / 2 h / 20 °C / Inert atmosphere

9: triethylamine / 2 h / 50 - 70 °C

With bis-triphenylphosphine-palladium(II) chloride; lithium borohydride; tetrabutylammomium bromide; sodium carbonate; triethylamine; sodium iodide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm501778s

Reference yield:

: 1009628-23-2
(S)-(2-chloro-6-(3-methylmorpholino)pyrimidin-4-yl)methyl methanesulfonate

: 1101800-09-2
3-cyclopropyl-1-[4-[4-(1-cyclopropylsulfonylcyclopropyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]urea

Guidance literature:: Multi-step reaction with 6 steps

1: sodium iodide / 20 h / 50 °C

2: acetonitrile / 3 h / 90 °C

3: tetrabutylammomium bromide; sodium hydroxide / water / 4 h / 60 - 70 °C

4: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; N,N-dimethyl-formamide; ethanol; 1,2-dimethoxyethane / 5 h / 80 - 95 °C / Inert atmosphere

5: sodium carbonate / 1,4-dioxane / 2 h / 20 °C / Inert atmosphere

6: triethylamine / 2 h / 50 - 70 °C

With bis-triphenylphosphine-palladium(II) chloride; tetrabutylammomium bromide; sodium carbonate; triethylamine; sodium iodide; sodium hydroxide; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm501778s