N⁵--N¹,N⁹-bis(2,3-dihydroxybenzoyl)bis(4-aminobutyl)amine

Base Information

• Chemical Name: N⁵--N¹,N⁹-bis(2,3-dihydroxybenzoyl)bis(4-aminobutyl)amine
• CAS No.: 78217-82-0
• Molecular Formula: C₃₁H₃₆N₄O₉
• Molecular Weight: 608.648
• Mol file: 78217-82-0.mol

Synonyms:N⁵--N¹,N⁹-bis(2,3-dihydroxybenzoyl)bis(4-aminobutyl)amine

Chemical Property of N⁵--N¹,N⁹-bis(2,3-dihydroxybenzoyl)bis(4-aminobutyl)amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁵--N¹,N⁹-bis(2,3-dihydroxybenzoyl)bis(4-aminobutyl)amine

There total 7 articles about N⁵--N¹,N⁹-bis(2,3-dihydroxybenzoyl)bis(4-aminobutyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

N5--N1,N9-bis(2,3-dimethoxybenzoyl)bis(4-aminobutyl)amine (78217-80-8) → N5--N1,N9-bis(2,3-dihydroxybenzoyl)bis(4-aminobutyl)amine (78217-82-0)

Guidance literature:

With boron tribromide; In dichloromethane; for 18h; 0 deg C to room temperature;

DOI:10.1021/jo00335a041

Reference yield:

N5-Benzylhomospermidine (78217-68-2) → N5--N1,N9-bis(2,3-dihydroxybenzoyl)bis(4-aminobutyl)amine (78217-82-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 97 percent / triethylamine / CH₂Cl₂ / 0 deg C to room temperature

2: 99 percent / 1) H₂, 2) NaOMe / 1) PdCl₂ / 1) glacial acetic acid, room temperature, 2) MeOH, 30 min

3: 95 percent / triethylamine / CH₂Cl₂ / 40 h / -78 deg C to room temperature

4: 94 percent / BBr₃ / CH₂Cl₂ / 18 h / 0 deg C to room temperature

With hydrogen; sodium methylate; boron tribromide; triethylamine; palladium dichloride; In dichloromethane;

DOI:10.1021/jo00335a041

Reference yield:

N,N-Bis(3-cyanopropyl)-benzylamine (78217-67-1) → N5--N1,N9-bis(2,3-dihydroxybenzoyl)bis(4-aminobutyl)amine (78217-82-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 66 percent / LiAlH₄, AlCl₃

2: 97 percent / triethylamine / CH₂Cl₂ / 0 deg C to room temperature

3: 99 percent / 1) H₂, 2) NaOMe / 1) PdCl₂ / 1) glacial acetic acid, room temperature, 2) MeOH, 30 min

4: 95 percent / triethylamine / CH₂Cl₂ / 40 h / -78 deg C to room temperature

5: 94 percent / BBr₃ / CH₂Cl₂ / 18 h / 0 deg C to room temperature

With lithium aluminium tetrahydride; aluminium trichloride; hydrogen; sodium methylate; boron tribromide; triethylamine; palladium dichloride; In dichloromethane;

DOI:10.1021/jo00335a041

upstream raw materials:

N⁵--N¹,N⁹-bis(2,3-dimethoxybenzoyl)bis(4-aminobutyl)amine

Salicyluric acid

N⁵-Benzylhomospermidine

N,N-Bis(3-cyanopropyl)-benzylamine