1-(methoxymethoxy)-4-[3-(tert-butyldimethylsiloxy)-propyl]-2-[4-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-benzene

Base Information

• Chemical Name: 1-(methoxymethoxy)-4-[3-(tert-butyldimethylsiloxy)-propyl]-2-[4-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-benzene
• CAS No.: 886054-82-6
• Molecular Formula: C₃₂H₅₄O₅Si₂
• Molecular Weight: 574.949

Synonyms:1-(methoxymethoxy)-4-[3-(tert-butyldimethylsiloxy)-propyl]-2-[4-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-benzene

Chemical Property of 1-(methoxymethoxy)-4-[3-(tert-butyldimethylsiloxy)-propyl]-2-[4-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(methoxymethoxy)-4-[3-(tert-butyldimethylsiloxy)-propyl]-2-[4-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-benzene

There total 9 articles about 1-(methoxymethoxy)-4-[3-(tert-butyldimethylsiloxy)-propyl]-2-[4-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-chloro-3-[2-chloro-4-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-2-(methoxymethoxy)-5-[3-(tert-butyldimethylsiloxy)propyl]benzene (886054-92-8) → 1-(methoxymethoxy)-4-[3-(tert-butyldimethylsiloxy)-propyl]-2-[4-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-benzene (886054-82-6)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In ethanol; at 60 ℃; for 5h;

DOI:10.1016/j.bmc.2005.11.055

Reference yield:

3-(4'-hydroxyphenyl)-1-propyl acetate (80373-18-8) → 1-(methoxymethoxy)-4-[3-(tert-butyldimethylsiloxy)-propyl]-2-[4-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-benzene (886054-82-6)

Guidance literature:

Multi-step reaction with 9 steps

1.1: 64 percent / SO₂Cl₂ / 5 h / 0 °C

2.1: 100 percent / pyridine*HBr₃; pyridine / CHCl₃ / 3 h / 0 °C

3.1: 50 percent / LiClO₄ / Electrochemical reaction

4.1: 70 percent / Zn; AcOH / tetrahydrofuran / 0 °C

5.1: 100 percent / DIPEA / CH₂Cl₂

6.1: 100 percent / K₂CO₃; MeOH / 20 °C

7.1: 100 percent / imidazole / dimethylformamide / 6 h

8.1: n-BuLi / tetrahydrofuran; hexane / 0.05 h / -78 °C

8.2: B(OMe)3 / tetrahydrofuran; hexane / 2 h

8.3: 14 percent / H₂O₂; NaOH / tetrahydrofuran; hexane; H₂O / 0 °C

9.1: 92 percent / HCO₂NH₄ / Pd/C / ethanol / 5 h / 60 °C

With pyridine; 1H-imidazole; methanol; n-butyllithium; sulfuryl dichloride; pyridinium perbromide hydrobromide; ammonium formate; lithium perchlorate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2005.11.055

Reference yield:

acetic acid 3-(3-chloro-4-hydroxy-phenyl)-propyl ester (704912-98-1) → 1-(methoxymethoxy)-4-[3-(tert-butyldimethylsiloxy)-propyl]-2-[4-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-benzene (886054-82-6)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 100 percent / pyridine*HBr₃; pyridine / CHCl₃ / 3 h / 0 °C

2.1: 50 percent / LiClO₄ / Electrochemical reaction

3.1: 70 percent / Zn; AcOH / tetrahydrofuran / 0 °C

4.1: 100 percent / DIPEA / CH₂Cl₂

5.1: 100 percent / K₂CO₃; MeOH / 20 °C

6.1: 100 percent / imidazole / dimethylformamide / 6 h

7.1: n-BuLi / tetrahydrofuran; hexane / 0.05 h / -78 °C

7.2: B(OMe)3 / tetrahydrofuran; hexane / 2 h

7.3: 14 percent / H₂O₂; NaOH / tetrahydrofuran; hexane; H₂O / 0 °C

8.1: 92 percent / HCO₂NH₄ / Pd/C / ethanol / 5 h / 60 °C

With pyridine; 1H-imidazole; methanol; n-butyllithium; pyridinium perbromide hydrobromide; ammonium formate; lithium perchlorate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; palladium on activated charcoal; In tetrahydrofuran; ethanol; hexane; dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2005.11.055

upstream raw materials:

1-chloro-3-[2-chloro-4-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-2-(methoxymethoxy)-5-[3-(tert-butyldimethylsiloxy)propyl]benzene

acetic acid 3-(3-chloro-4-hydroxy-phenyl)-propyl ester

3-(4'-hydroxyphenyl)-1-propyl acetate

3-(5-bromo-3-chloro-4-hydroxyphenyl)propyl acetate

Downstream raw materials:

1-(2,4-bis-methoxymethoxy-phenyl)-3-(3-{4-[3-(2,4-bis-methoxymethoxy-phenyl)-3-oxo-propyl]-phenoxy}-4-methoxymethoxy-phenyl)-propan-1-one

N-methoxy-3-[4-[2-(methoxymethoxy)-5-(2-(N-methoxy-N-methylcarbamoyl)ethyl)phenoxy]phenyl]-N-methylpropanamide

3-[4-(5-(2-carboxyethyl)-2-(methoxymethoxy)phenoxy)phenyl]propionic acid

3-[4-(2-(methoxymethoxy)-5-(3-oxopropyl)phenoxy)-phenyl]propanal

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 886054-82-6 1-(methoxymethoxy)-4-[3-(tert-butyldimethylsiloxy)-propyl]-2-[4-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-benzene

Send

Send

Metric Ton KG G Pound L ML

Send

Send