1-chloro-3-[2-chloro-4-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-2-(methoxymethoxy)-5-[3-(tert-butyldimethylsiloxy)propyl]benzene

Base Information

• Chemical Name: 1-chloro-3-[2-chloro-4-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-2-(methoxymethoxy)-5-[3-(tert-butyldimethylsiloxy)propyl]benzene
• CAS No.: 886054-92-8
• Molecular Formula: C₃₂H₅₂Cl₂O₅Si₂
• Molecular Weight: 643.839
• Mol file: 886054-92-8.mol

Synonyms:1-chloro-3-[2-chloro-4-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-2-(methoxymethoxy)-5-[3-(tert-butyldimethylsiloxy)propyl]benzene

Chemical Property of 1-chloro-3-[2-chloro-4-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-2-(methoxymethoxy)-5-[3-(tert-butyldimethylsiloxy)propyl]benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-chloro-3-[2-chloro-4-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-2-(methoxymethoxy)-5-[3-(tert-butyldimethylsiloxy)propyl]benzene

There total 8 articles about 1-chloro-3-[2-chloro-4-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-2-(methoxymethoxy)-5-[3-(tert-butyldimethylsiloxy)propyl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

C32H51BrCl2O5Si2 (704913-01-9) → 1-chloro-3-[2-chloro-4-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-2-(methoxymethoxy)-5-[3-(tert-butyldimethylsiloxy)propyl]benzene (886054-92-8) + 3-chloro-2-[3-chloro-2-(methoxymethoxy)-5-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-5-[3-(tert-butyldimethylsiloxy)propyl]phenol (704912-92-5)

Guidance literature:

C₃₂H₅₁BrCl₂O₅Si₂; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.05h;

With Trimethyl borate; In tetrahydrofuran; hexane; for 2h;

With sodium hydroxide; dihydrogen peroxide; In tetrahydrofuran; hexane; water; at 0 ℃;

DOI:10.1016/j.bmc.2005.11.055

Reference yield:

acetic acid 3-(3-chloro-4-hydroxy-phenyl)-propyl ester (704912-98-1) → 1-chloro-3-[2-chloro-4-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-2-(methoxymethoxy)-5-[3-(tert-butyldimethylsiloxy)propyl]benzene (886054-92-8)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 100 percent / pyridine*HBr₃; pyridine / CHCl₃ / 3 h / 0 °C

2.1: 50 percent / LiClO₄ / Electrochemical reaction

3.1: 70 percent / Zn; AcOH / tetrahydrofuran / 0 °C

4.1: 100 percent / DIPEA / CH₂Cl₂

5.1: 100 percent / K₂CO₃; MeOH / 20 °C

6.1: 100 percent / imidazole / dimethylformamide / 6 h

7.1: n-BuLi / tetrahydrofuran; hexane / 0.05 h / -78 °C

7.2: B(OMe)3 / tetrahydrofuran; hexane / 2 h

7.3: 14 percent / H₂O₂; NaOH / tetrahydrofuran; hexane; H₂O / 0 °C

With pyridine; 1H-imidazole; methanol; n-butyllithium; pyridinium perbromide hydrobromide; lithium perchlorate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; hexane; dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2005.11.055

Reference yield:

3-(4'-hydroxyphenyl)-1-propyl acetate (80373-18-8) → 1-chloro-3-[2-chloro-4-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-2-(methoxymethoxy)-5-[3-(tert-butyldimethylsiloxy)propyl]benzene (886054-92-8)

Guidance literature:

Multi-step reaction with 8 steps

1.1: 64 percent / SO₂Cl₂ / 5 h / 0 °C

2.1: 100 percent / pyridine*HBr₃; pyridine / CHCl₃ / 3 h / 0 °C

3.1: 50 percent / LiClO₄ / Electrochemical reaction

4.1: 70 percent / Zn; AcOH / tetrahydrofuran / 0 °C

5.1: 100 percent / DIPEA / CH₂Cl₂

6.1: 100 percent / K₂CO₃; MeOH / 20 °C

7.1: 100 percent / imidazole / dimethylformamide / 6 h

8.1: n-BuLi / tetrahydrofuran; hexane / 0.05 h / -78 °C

8.2: B(OMe)3 / tetrahydrofuran; hexane / 2 h

8.3: 14 percent / H₂O₂; NaOH / tetrahydrofuran; hexane; H₂O / 0 °C

With pyridine; 1H-imidazole; methanol; n-butyllithium; sulfuryl dichloride; pyridinium perbromide hydrobromide; lithium perchlorate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; hexane; dichloromethane; chloroform; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2005.11.055

upstream raw materials:

C₃₂H₅₁BrCl₂O₅Si₂

acetic acid 3-(3-chloro-4-hydroxy-phenyl)-propyl ester

3-(4'-hydroxyphenyl)-1-propyl acetate

3-(5-bromo-3-chloro-4-hydroxyphenyl)propyl acetate

Downstream raw materials:

1-(methoxymethoxy)-4-[3-(tert-butyldimethylsiloxy)-propyl]-2-[4-(3-(tert-butyldimethylsiloxy)propyl)phenoxy]-benzene

3-[4-(2-(methoxymethoxy)-5-(3-oxopropyl)phenoxy)-phenyl]propanal

3-{3-[4-(3-hydroxy-propyl)-phenoxy]-4-methoxymethoxy-phenyl}-propan-1-ol

3-[4-(5-(2-carboxyethyl)-2-(methoxymethoxy)phenoxy)phenyl]propionic acid