3-<4-(2-tert-butyldimethylsilyloxyethyl)piperazinomethyl>-6,7-dimethoxy-2-(methoxycarbonyl)-1-(3,4,5-trimethoxyphenyl)naphthalene

Base Information

Chemical Name:3-<4-(2-tert-butyldimethylsilyloxyethyl)piperazinomethyl>-6,7-dimethoxy-2-(methoxycarbonyl)-1-(3,4,5-trimethoxyphenyl)naphthalene
CAS No.:225516-55-2
Molecular Formula:C₃₆H₅₀N₂O₉Si
Molecular Weight:682.886
Hs Code.:

Synonyms:3-<4-(2-tert-butyldimethylsilyloxyethyl)piperazinomethyl>-6,7-dimethoxy-2-(methoxycarbonyl)-1-(3,4,5-trimethoxyphenyl)naphthalene

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Chemical Property of 3-<4-(2-tert-butyldimethylsilyloxyethyl)piperazinomethyl>-6,7-dimethoxy-2-(methoxycarbonyl)-1-(3,4,5-trimethoxyphenyl)naphthalene

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Technology Process of 3-<4-(2-tert-butyldimethylsilyloxyethyl)piperazinomethyl>-6,7-dimethoxy-2-(methoxycarbonyl)-1-(3,4,5-trimethoxyphenyl)naphthalene

There total 8 articles about 3-<4-(2-tert-butyldimethylsilyloxyethyl)piperazinomethyl>-6,7-dimethoxy-2-(methoxycarbonyl)-1-(3,4,5-trimethoxyphenyl)naphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 225516-43-8
3-[4-(2-hydroxy-ethyl)-piperazine-1-carbonyl]-6,7-dimethoxy-1-(3,4,5-trimethoxy-phenyl)-naphthalene-2-carboxylic acid methyl ester

: 225516-55-2
3-<4-(2-tert-butyldimethylsilyloxyethyl)piperazinomethyl>-6,7-dimethoxy-2-(methoxycarbonyl)-1-(3,4,5-trimethoxyphenyl)naphthalene

Guidance literature:: With 1H-imidazole; In tetrahydrofuran; Ambient temperature;
DOI:10.1021/jm9807048

Reference yield:

: 103-76-4
1-(2-hydroxyethyl)piperazine

: 225516-55-2
3-<4-(2-tert-butyldimethylsilyloxyethyl)piperazinomethyl>-6,7-dimethoxy-2-(methoxycarbonyl)-1-(3,4,5-trimethoxyphenyl)naphthalene

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / 1-hydroxybenzotriazole hydrate, 1,3-dicyclohexylcarbodiimide / CH₂Cl₂ / Ambient temperature

2: 96 percent / imidazole / tetrahydrofuran / Ambient temperature

With 1H-imidazole; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm9807048

Reference yield:

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 225516-55-2
3-<4-(2-tert-butyldimethylsilyloxyethyl)piperazinomethyl>-6,7-dimethoxy-2-(methoxycarbonyl)-1-(3,4,5-trimethoxyphenyl)naphthalene

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-BuLi / 1.) THF, -78 deg C, 30 min, 2.) THF, -78 deg C, 30 min

2: AcOH / toluene / 2 h / Heating

3: TFA / toluene / Ambient temperature

4: 94 percent / 2 N aq. NaOH / methanol / 0.5 h / Heating

5: 88 percent / 1-hydroxybenzotriazole hydrate, 1,3-dicyclohexylcarbodiimide / CH₂Cl₂ / Ambient temperature

6: 96 percent / imidazole / tetrahydrofuran / Ambient temperature

With 1H-imidazole; sodium hydroxide; n-butyllithium; acetic acid; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jm9807048