4-carboxy-1,3-bis(α-chloro-α-hydroxybenzyl)-2,5-diphenylcyclopentaneacetic acid di-γ-lactone

Base Information

• Chemical Name: 4-carboxy-1,3-bis(α-chloro-α-hydroxybenzyl)-2,5-diphenylcyclopentaneacetic acid di-γ-lactone
• CAS No.: 80716-64-9
• Molecular Formula: C₃₄H₂₆Cl₂O₄
• Molecular Weight: 569.484

Synonyms:4-carboxy-1,3-bis(α-chloro-α-hydroxybenzyl)-2,5-diphenylcyclopentaneacetic acid di-γ-lactone

Chemical Property of 4-carboxy-1,3-bis(α-chloro-α-hydroxybenzyl)-2,5-diphenylcyclopentaneacetic acid di-γ-lactone

Chemical Property:

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Technology Process of 4-carboxy-1,3-bis(α-chloro-α-hydroxybenzyl)-2,5-diphenylcyclopentaneacetic acid di-γ-lactone

There total 2 articles about 4-carboxy-1,3-bis(α-chloro-α-hydroxybenzyl)-2,5-diphenylcyclopentaneacetic acid di-γ-lactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

3-Benzoyl 4-Phenylisocrotonic acid (80716-63-8) → 4-carboxy-1,3-bis(α-chloro-α-hydroxybenzyl)-2,5-diphenylcyclopentaneacetic acid di-γ-lactone (80716-64-9)

Guidance literature:

With acetyl chloride; Ambient temperature;

DOI:10.1016/S0040-4039(01)82018-9

Reference yield:

3-Benzoyl 4-Phenylisocrotonic acid (80716-63-8) → C34H25ClO4 (81555-52-4) + C34H25ClO4 (80716-65-0) + 4-carboxy-1,3-bis(α-chloro-α-hydroxybenzyl)-2,5-diphenylcyclopentaneacetic acid di-γ-lactone (80716-64-9)

Guidance literature:

With acetyl chloride; Yield given. Multistep reaction. Yields of byproduct given; 1.) RT, 7 d, 2.) C₆H₆, CH₂C₂, reflux, 20 h;

DOI:10.1021/jo00134a014

Reference yield: 95.0%

methanol (67-56-1) + 4-carboxy-1,3-bis(α-chloro-α-hydroxybenzyl)-2,5-diphenylcyclopentaneacetic acid di-γ-lactone (80716-64-9) → 4-carboxy-1,3-bis(α-methoxy-α-hydroxybenzyl)-2,5-diphenylcyclopentaneacetic acid di-γ-lactone (81555-51-3)

Guidance literature:

for 20h; Heating;

DOI:10.1021/jo00134a014

upstream raw materials:

3-Benzoyl 4-Phenylisocrotonic acid

Downstream raw materials:

4-carboxy-1,3-bis(α-methoxy-α-hydroxybenzyl)-2,5-diphenylcyclopentaneacetic acid di-γ-lactone

trans-8,8a-dihydro-4,7,8,8a-tetraphenylbenzo<1,2-b:4,5-c'>difuran-2,5-dione

1-(α-hydroxybenzyl)-3-benzyl-cis-4-carboxy-2,5-diphenylcyclopentaneacetic acid γ-lactone

(1R,8R,9S,10R,11S)-9-Benzoyl-5,10,11-triphenyl-4,6-dioxa-tricyclo[6.2.1.0^1,5]undecane-3,7-dione

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