N--L-proline benzyl ester

Base Information

Chemical Name:N--L-proline benzyl ester
CAS No.:85304-36-5
Molecular Formula:C₄₅H₄₃N₃O₆
Molecular Weight:721.853
Hs Code.:

N-<N-(2S-2-benzamido-3-phenylpropyl)-N-(9-fluorenylmethyloxycarbonyl)aminoacetyl>-L-proline benzyl ester

Synonyms:N--L-proline benzyl ester

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Chemical Property of N--L-proline benzyl ester

Chemical Property:

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Technology Process of N--L-proline benzyl ester

There total 5 articles about N--L-proline benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 16652-71-4
benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride

: 85304-35-4
N-(2S-2-benzamido-3-phenylpropyl)-N-(9-fluorenylmethyloxy-carbonyl)aminoacetic acid

: 85304-36-5
N--L-proline benzyl ester

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; 5 deg C, 0.5 h; RT, 45 h;
DOI:10.1002/jps.2600720115

Reference yield:

: 85304-32-1
N-(2S-2-benzyloxycarbonylamino-3-phenylpropyl)-N-(9-fluorenylmethyloxy-carbonyl)aminoethanol

: 85304-36-5
N--L-proline benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 10percent Pd/C / acetic acid / 2 h

2: NaHCO₃ / CH₂Cl₂ / 21 h / Ambient temperature

3: CrO₃ / acetone; aq. H₂SO₄ / 1 h / Ambient temperature

4: 73 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide, Et₃N / CH₂Cl₂ / 5 deg C, 0.5 h; RT, 45 h

With chromium(VI) oxide; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In dichloromethane; sulfuric acid; acetic acid; acetone;
DOI:10.1002/jps.2600720115

Reference yield:

: 98-88-4
benzoyl chloride

: 85304-36-5
N--L-proline benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaHCO₃ / CH₂Cl₂ / 21 h / Ambient temperature

2: CrO₃ / acetone; aq. H₂SO₄ / 1 h / Ambient temperature

3: 73 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide, Et₃N / CH₂Cl₂ / 5 deg C, 0.5 h; RT, 45 h

With chromium(VI) oxide; sodium hydrogencarbonate; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; sulfuric acid; acetone;
DOI:10.1002/jps.2600720115