3-(4-cyclopropylphenoxy)-1-(3-ethyl-4-(pyrrolidin-1-yl)phenyl)pyrrolidin-2-one

Base Information

Chemical Name:3-(4-cyclopropylphenoxy)-1-(3-ethyl-4-(pyrrolidin-1-yl)phenyl)pyrrolidin-2-one
CAS No.:1574538-38-7
Molecular Formula:C₂₅H₃₀N₂O₂
Molecular Weight:390.525
Hs Code.:

Synonyms:3-(4-cyclopropylphenoxy)-1-(3-ethyl-4-(pyrrolidin-1-yl)phenyl)pyrrolidin-2-one

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Chemical Property of 3-(4-cyclopropylphenoxy)-1-(3-ethyl-4-(pyrrolidin-1-yl)phenyl)pyrrolidin-2-one

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Technology Process of 3-(4-cyclopropylphenoxy)-1-(3-ethyl-4-(pyrrolidin-1-yl)phenyl)pyrrolidin-2-one

There total 4 articles about 3-(4-cyclopropylphenoxy)-1-(3-ethyl-4-(pyrrolidin-1-yl)phenyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10292-61-2
4-cyclopropylphenol

: 1574541-76-6
3-ethyl-4-(pyrrolidin-1-yl)aniline

: 82820-87-9
2,4-dibromobutanoyl chloride

: 1574538-38-7
3-(4-cyclopropylphenoxy)-1-(3-ethyl-4-(pyrrolidin-1-yl)phenyl)pyrrolidin-2-one

Guidance literature:: 3-ethyl-4-(pyrrolidin-1-yl)aniline; 2,4-dibromobutanoyl chloride; With triethylamine; In chloroform; at 0 - 20 ℃; Inert atmosphere;

With potassium hydroxide; In chloroform; water; for 5h; Inert atmosphere;

4-cyclopropylphenol; In chloroform; water; at 70 ℃; for 40h; Inert atmosphere;

Reference yield:

: 1260655-13-7
1-(2-bromo-4-nitrophenyl)pyrrolidine

: 1574538-38-7
3-(4-cyclopropylphenoxy)-1-(3-ethyl-4-(pyrrolidin-1-yl)phenyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C / Inert atmosphere

2.1: palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C

3.1: triethylamine / chloroform / 0 - 20 °C / Inert atmosphere

3.2: AMBERLITE? IRA-400 / 5 h / Inert atmosphere

3.3: 40 h / 70 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; palladium on activated charcoal; hydrogen; caesium carbonate; triethylamine; In methanol; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 1574541-75-5
1-(2-ethyl-4-nitrophenyl)pyrrolidine

: 1574538-38-7
3-(4-cyclopropylphenoxy)-1-(3-ethyl-4-(pyrrolidin-1-yl)phenyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium on activated charcoal; hydrogen / methanol / 2 h / 20 °C

2.1: triethylamine / chloroform / 0 - 20 °C / Inert atmosphere

2.2: AMBERLITE? IRA-400 / 5 h / Inert atmosphere

2.3: 40 h / 70 °C / Inert atmosphere

With palladium on activated charcoal; hydrogen; triethylamine; In methanol; chloroform;