(E)-((3-methyl-2-pyridinyl)methylene)-1-(trimethylsilyl)methylamine

Base Information

• Chemical Name: (E)-((3-methyl-2-pyridinyl)methylene)-1-(trimethylsilyl)methylamine
• CAS No.: 1590379-17-1
• Molecular Formula: C₁₁H₁₈N₂Si
• Molecular Weight: 206.363
• Mol file: 1590379-17-1.mol

Synonyms:(E)-((3-methyl-2-pyridinyl)methylene)-1-(trimethylsilyl)methylamine

Chemical Property of (E)-((3-methyl-2-pyridinyl)methylene)-1-(trimethylsilyl)methylamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (E)-((3-methyl-2-pyridinyl)methylene)-1-(trimethylsilyl)methylamine

There total 1 articles about (E)-((3-methyl-2-pyridinyl)methylene)-1-(trimethylsilyl)methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methylpyridine-2-carboxaldehyde (55589-47-4) + N-trimethylsilylmethylamine (18166-02-4) → (E)-((3-methyl-2-pyridinyl)methylene)-1-(trimethylsilyl)methylamine (1590379-17-1)

Guidance literature:

With magnesium sulfate; In dichloromethane; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/ol5007373

Reference yield:

N-phenyl-maleimide (941-69-5) + (E)-((3-methyl-2-pyridinyl)methylene)-1-(trimethylsilyl)methylamine (1590379-17-1) → (3aS,4S,6aR)-4-(3-methyl-2-pyridinyl)-2-phenyltetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione (1590379-26-2) + (3aR,4R,6aS)-4-(3-methyl-2-pyridinyl)-2-phenyltetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione

Guidance literature:

With tetrakis(actonitrile)copper(I) hexafluorophosphate; Walphos; water; In tetrahydrofuran; at -10 ℃; Overall yield = 35.0 mg; stereoselective reaction; Inert atmosphere;

DOI:10.1021/ol5007373

upstream raw materials:

3-methylpyridine-2-carboxaldehyde

N-trimethylsilylmethylamine

Downstream raw materials:

(3aS,4S,6aR)-4-(3-methyl-2-pyridinyl)-2-phenyltetrahydropyrrolo[3,4-c]pyrrole-1,3(2H,3aH)-dione