1-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-{[4-(1H-tetrazol-1-yl)phenoxy]methyl}-pyrazole-5-carbonitrile

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Chemical Name:1-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-{[4-(1H-tetrazol-1-yl)phenoxy]methyl}-pyrazole-5-carbonitrile
CAS No.:1379603-65-2
Molecular Formula:C₂₃H₂₄N₁₀O
Molecular Weight:456.51
Hs Code.:

Synonyms:1-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-{[4-(1H-tetrazol-1-yl)phenoxy]methyl}-pyrazole-5-carbonitrile

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Chemical Property of 1-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-{[4-(1H-tetrazol-1-yl)phenoxy]methyl}-pyrazole-5-carbonitrile

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Technology Process of 1-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-{[4-(1H-tetrazol-1-yl)phenoxy]methyl}-pyrazole-5-carbonitrile

There total 9 articles about 1-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-{[4-(1H-tetrazol-1-yl)phenoxy]methyl}-pyrazole-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 1379604-33-7
1-piperidin-4-yl-4-{[4-(1H-tetrazol-1-yl)phenoxy]methyl}-1H-pyrazole-5-carbonitrile

: 111196-81-7
2-chloro-5-ethylpyrimidine

: 1379603-65-2
1-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-{[4-(1H-tetrazol-1-yl)phenoxy]methyl}-pyrazole-5-carbonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 - 120 ℃; for 54h; sealed tube;

Reference yield:

: 1258001-22-7
tert-butyl 4-(5-bromo-4-ethoxycarbonylpyrazol-1-yl)piperidine-1-carboxylate

: 1379603-65-2
1-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-{[4-(1H-tetrazol-1-yl)phenoxy]methyl}-pyrazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 15 h / 0 - 20 °C / Reflux

1.2: 0.33 h / 20 °C / Cooling with ice

2.1: N,N-dimethyl-formamide / 4 h / 165 °C

3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.58 h / 0 °C

3.2: 0 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 54 h / 20 - 120 °C / sealed tube

With dimethylsulfide borane complex; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 1379603-65-2
1-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-{[4-(1H-tetrazol-1-yl)phenoxy]methyl}-pyrazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 19 h / 0 - 20 °C

2.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 2.75 h / -78 - -10 °C

2.2: 20 h / -10 - 20 °C

3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.58 h / 0 °C

3.2: 0 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 54 h / 20 - 120 °C / sealed tube

With diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;