1-(2-(2,6-dimethylphenyl)-4-methoxy-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-4-methylpentane-1,3-dione

Base Information

Chemical Name:1-(2-(2,6-dimethylphenyl)-4-methoxy-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-4-methylpentane-1,3-dione
CAS No.:1421253-30-6
Molecular Formula:C₂₂H₂₇N₃O₃
Molecular Weight:381.475
Hs Code.:

Synonyms:1-(2-(2,6-dimethylphenyl)-4-methoxy-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-4-methylpentane-1,3-dione

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Chemical Property of 1-(2-(2,6-dimethylphenyl)-4-methoxy-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-4-methylpentane-1,3-dione

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Technology Process of 1-(2-(2,6-dimethylphenyl)-4-methoxy-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-4-methylpentane-1,3-dione

There total 4 articles about 1-(2-(2,6-dimethylphenyl)-4-methoxy-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-4-methylpentane-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42558-54-3
Methyl 4-methyl-3-oxopentanoate

: 1421253-29-3
2-(2,6-dimethylphenyl)-4-methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

: 1421253-30-6
1-(2-(2,6-dimethylphenyl)-4-methoxy-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-4-methylpentane-1,3-dione

Guidance literature:: With dmap; In toluene; at 150 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 1421067-10-8
6-benzyl-2-chloro-4-methoxy-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

: 1421253-30-6
1-(2-(2,6-dimethylphenyl)-4-methoxy-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-4-methylpentane-1,3-dione

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 48 h / 100 °C / Inert atmosphere

2: acetic acid; 20% palladium hydroxide-activated charcoal; hydrogen / water; tetrahydrofuran / 16.5 h / 20 - 40 °C / Inert atmosphere

3: dmap / toluene / 0.5 h / 150 °C / Microwave irradiation

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 20% palladium hydroxide-activated charcoal; hydrogen; sodium carbonate; acetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; water; toluene;

Reference yield:

: 778574-06-4
6-benzyl-2,4-dichloro-5,6,7,8-tetrahydropyrido[4,3-d]-pyrimidine

: 1421253-30-6
1-(2-(2,6-dimethylphenyl)-4-methoxy-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl)-4-methylpentane-1,3-dione

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / 0.75 h / 0 - 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,2-dimethoxyethane / 48 h / 100 °C / Inert atmosphere

3: acetic acid; 20% palladium hydroxide-activated charcoal; hydrogen / water; tetrahydrofuran / 16.5 h / 20 - 40 °C / Inert atmosphere

4: dmap / toluene / 0.5 h / 150 °C / Microwave irradiation

With methanol; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 20% palladium hydroxide-activated charcoal; hydrogen; sodium carbonate; acetic acid; In tetrahydrofuran; 1,2-dimethoxyethane; water; toluene;