2-(2,4-difluorophenyl)-1-(4-(4-propyl-1H-1,2,3-triazol-1-yl)piperidin-1-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

Base Information

Chemical Name:2-(2,4-difluorophenyl)-1-(4-(4-propyl-1H-1,2,3-triazol-1-yl)piperidin-1-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol
CAS No.:1616999-96-2
Molecular Formula:C₂₁H₂₇F₂N₇O
Molecular Weight:431.488
Hs Code.:

Synonyms:2-(2,4-difluorophenyl)-1-(4-(4-propyl-1H-1,2,3-triazol-1-yl)piperidin-1-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

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Chemical Property of 2-(2,4-difluorophenyl)-1-(4-(4-propyl-1H-1,2,3-triazol-1-yl)piperidin-1-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

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Technology Process of 2-(2,4-difluorophenyl)-1-(4-(4-propyl-1H-1,2,3-triazol-1-yl)piperidin-1-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

There total 7 articles about 2-(2,4-difluorophenyl)-1-(4-(4-propyl-1H-1,2,3-triazol-1-yl)piperidin-1-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.8%

: 627-19-0
1-Pentyne

: 1616999-94-0
1-(4-azidopiperidin-1-yl)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl) propan-2-ol

: 1616999-96-2
2-(2,4-difluorophenyl)-1-(4-(4-propyl-1H-1,2,3-triazol-1-yl)piperidin-1-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 50 ℃; for 12h;
DOI:10.1016/j.ejmech.2014.05.079

Reference yield:

: 1373256-20-2
5 1-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-piperidin-4-ol

: 1616999-96-2
2-(2,4-difluorophenyl)-1-(4-(4-propyl-1H-1,2,3-triazol-1-yl)piperidin-1-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 1.5 h / 0 °C

2: sodium azide / N,N-dimethyl-formamide / 6 h / 40 °C

3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 12 h / 50 °C

With sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; triethylamine; In dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2014.05.079

Reference yield:

: C₁₇H₂₂F₂N₄O₄S

: 1616999-96-2
2-(2,4-difluorophenyl)-1-(4-(4-propyl-1H-1,2,3-triazol-1-yl)piperidin-1-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / N,N-dimethyl-formamide / 6 h / 40 °C

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 12 h / 50 °C

With sodium azide; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.ejmech.2014.05.079