1-(4-azidopiperidin-1-yl)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl) propan-2-ol

Base Information

Chemical Name:1-(4-azidopiperidin-1-yl)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl) propan-2-ol
CAS No.:1616999-94-0
Molecular Formula:C₁₆H₁₉F₂N₇O
Molecular Weight:363.37
Hs Code.:

Synonyms:1-(4-azidopiperidin-1-yl)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl) propan-2-ol

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Chemical Property of 1-(4-azidopiperidin-1-yl)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl) propan-2-ol

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Technology Process of 1-(4-azidopiperidin-1-yl)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl) propan-2-ol

There total 6 articles about 1-(4-azidopiperidin-1-yl)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl) propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₂₂F₂N₄O₄S

: 1616999-94-0
1-(4-azidopiperidin-1-yl)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl) propan-2-ol

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 40 ℃; for 6h;
DOI:10.1016/j.ejmech.2014.05.079

Reference yield:

: 1373256-20-2
5 1-[2-(2,4-difluorophenyl)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)-propyl]-piperidin-4-ol

: 1616999-94-0
1-(4-azidopiperidin-1-yl)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl) propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1.5 h / 0 °C

2: sodium azide / N,N-dimethyl-formamide / 6 h / 40 °C

With sodium azide; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.05.079

Reference yield:

: 372-18-9
1,3-Difluorobenzene

: 1616999-94-0
1-(4-azidopiperidin-1-yl)-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl) propan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: aluminum (III) chloride / dichloromethane / 3 h / 40 °C

2: potassium carbonate / dichloromethane / 24 h / 20 °C

3: sodium hydroxide / toluene / 3 h / 60 °C

4: triethylamine / ethanol / 12 h / 78 °C

5: triethylamine / dichloromethane / 1.5 h / 0 °C

6: sodium azide / N,N-dimethyl-formamide / 6 h / 40 °C

With aluminum (III) chloride; sodium azide; potassium carbonate; triethylamine; sodium hydroxide; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2014.05.079