1-[3-(2,6-difluoro-4-methoxyphenyl)-5-methyl-3H-imidazol-4-yl]-4-methylpiperidine

Base Information

Chemical Name:1-[3-(2,6-difluoro-4-methoxyphenyl)-5-methyl-3H-imidazol-4-yl]-4-methylpiperidine
CAS No.:1245612-75-2
Molecular Formula:C₁₇H₂₁F₂N₃O
Molecular Weight:321.37
Hs Code.:

Synonyms:1-[3-(2,6-difluoro-4-methoxyphenyl)-5-methyl-3H-imidazol-4-yl]-4-methylpiperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[3-(2,6-difluoro-4-methoxyphenyl)-5-methyl-3H-imidazol-4-yl]-4-methylpiperidine

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Technology Process of 1-[3-(2,6-difluoro-4-methoxyphenyl)-5-methyl-3H-imidazol-4-yl]-4-methylpiperidine

There total 7 articles about 1-[3-(2,6-difluoro-4-methoxyphenyl)-5-methyl-3H-imidazol-4-yl]-4-methylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1245612-74-1
1-[3-(2,6-difluoro-4-methoxyphenyl)-5-methyl-2-methylsulfanyl-3H-imidazol-4-yl]-4-methylpiperidine

: 1245612-75-2
1-[3-(2,6-difluoro-4-methoxyphenyl)-5-methyl-3H-imidazol-4-yl]-4-methylpiperidine

Guidance literature:: With Raney-Nickel; In ethanol; for 1.5h; Inert atmosphere; Reflux;
DOI:10.1016/j.bmc.2012.10.052

Reference yield:

: 1245612-66-1
1-[2-(4-methylpiperidin-1-yl)-2-oxoethyl]-3-(2,4,6-trifluorophenyl)thiourea

: 1245612-75-2
1-[3-(2,6-difluoro-4-methoxyphenyl)-5-methyl-3H-imidazol-4-yl]-4-methylpiperidine

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / acetonitrile / 1 h / 20 °C / Inert atmosphere

2: Lawessons reagent / 1,2-dimethoxyethane / 16 h / 20 °C / Inert atmosphere

3: N-Bromosuccinimide / chloroform / 0.25 h / 20 °C / Inert atmosphere

4: caesium carbonate; Trimethylboroxine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; dichloromethane / 16 h / 90 °C / Inert atmosphere

5: sodium methylate / tetrahydrofuran; methanol / 0.5 h / Inert atmosphere; Reflux

6: Raney-Nickel / ethanol / 1.5 h / Inert atmosphere; Reflux

With Lawessons reagent; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; Trimethylboroxine; sodium methylate; potassium carbonate; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; chloroform; acetonitrile;
DOI:10.1016/j.bmc.2012.10.052

Reference yield:

: 1245612-68-3
4-methyl-1-[2-methylsulfanyl-3-(2,4,6-trifluorophenyl)-3H-imidazol-4-yl]piperidine

: 1245612-75-2
1-[3-(2,6-difluoro-4-methoxyphenyl)-5-methyl-3H-imidazol-4-yl]-4-methylpiperidine

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide / chloroform / 0.25 h / 20 °C / Inert atmosphere

2: caesium carbonate; Trimethylboroxine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; dichloromethane / 16 h / 90 °C / Inert atmosphere

3: sodium methylate / tetrahydrofuran; methanol / 0.5 h / Inert atmosphere; Reflux

4: Raney-Nickel / ethanol / 1.5 h / Inert atmosphere; Reflux

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; Trimethylboroxine; sodium methylate; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; chloroform;
DOI:10.1016/j.bmc.2012.10.052