((S)-2-amino-4-[4-(4-benzoylamino-phenoxy)-6-methoxy-quinolin-7-yloxy]-butyric acid cyclopentyl ester)

Base Information

Chemical Name:((S)-2-amino-4-[4-(4-benzoylamino-phenoxy)-6-methoxy-quinolin-7-yloxy]-butyric acid cyclopentyl ester)
CAS No.:914382-49-3
Molecular Formula:C₃₂H₃₃N₃O₆
Molecular Weight:555.631
Hs Code.:

Synonyms:((S)-2-amino-4-[4-(4-benzoylamino-phenoxy)-6-methoxy-quinolin-7-yloxy]-butyric acid cyclopentyl ester)

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Chemical Property of ((S)-2-amino-4-[4-(4-benzoylamino-phenoxy)-6-methoxy-quinolin-7-yloxy]-butyric acid cyclopentyl ester)

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Technology Process of ((S)-2-amino-4-[4-(4-benzoylamino-phenoxy)-6-methoxy-quinolin-7-yloxy]-butyric acid cyclopentyl ester)

There total 4 articles about ((S)-2-amino-4-[4-(4-benzoylamino-phenoxy)-6-methoxy-quinolin-7-yloxy]-butyric acid cyclopentyl ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 914382-73-3
(S)-4-[4-(4-benzoylamino-phenoxy)-6-methoxy-quinolin-7-yloxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester

: 914382-49-3
((S)-2-amino-4-[4-(4-benzoylamino-phenoxy)-6-methoxy-quinolin-7-yloxy]-butyric acid cyclopentyl ester)

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 16h;

Reference yield:

: 15457-50-8
p-benzoylaminophenol

: 914382-49-3
((S)-2-amino-4-[4-(4-benzoylamino-phenoxy)-6-methoxy-quinolin-7-yloxy]-butyric acid cyclopentyl ester)

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide / 7 h / 145 °C

2: ethanol; cyclohexene / 10 % Pd(OH)2/C / 18 h / Heating / reflux

3: potassium carbonate / N,N-dimethyl-formamide / 20 h / 35 °C

4: trifluoroacetic acid / dichloromethane / 16 h

With ethanol; potassium carbonate; trifluoroacetic acid; cyclohexene; 10 % Pd(OH)2/C; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 98-88-4
benzoyl chloride

: 914382-49-3
((S)-2-amino-4-[4-(4-benzoylamino-phenoxy)-6-methoxy-quinolin-7-yloxy]-butyric acid cyclopentyl ester)

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / N,N-dimethyl-formamide / 0.17 h / 0 °C

1.2: 18.08 - 18.33 h / 0 - 20 °C

2.1: N,N-dimethyl-formamide / 7 h / 145 °C

3.1: ethanol; cyclohexene / 10 % Pd(OH)2/C / 18 h / Heating / reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 35 °C

5.1: trifluoroacetic acid / dichloromethane / 16 h

With ethanol; potassium carbonate; triethylamine; trifluoroacetic acid; cyclohexene; 10 % Pd(OH)2/C; In dichloromethane; N,N-dimethyl-formamide;