(S)-4-[4-(4-benzoylamino-phenoxy)-6-methoxy-quinolin-7-yloxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester

Base Information

Chemical Name:(S)-4-[4-(4-benzoylamino-phenoxy)-6-methoxy-quinolin-7-yloxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester
CAS No.:914382-73-3
Molecular Formula:C₃₇H₄₁N₃O₈
Molecular Weight:655.748
Hs Code.:

Synonyms:(S)-4-[4-(4-benzoylamino-phenoxy)-6-methoxy-quinolin-7-yloxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester

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Chemical Property of (S)-4-[4-(4-benzoylamino-phenoxy)-6-methoxy-quinolin-7-yloxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester

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Technology Process of (S)-4-[4-(4-benzoylamino-phenoxy)-6-methoxy-quinolin-7-yloxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester

There total 8 articles about (S)-4-[4-(4-benzoylamino-phenoxy)-6-methoxy-quinolin-7-yloxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 914200-90-1
N-[4-(7-hydroxy-6-methoxy-quinolin-4-yloxy)-phenyl]-benzamide

: 914382-65-3
(S)-4-bromo-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester

: 914382-73-3
(S)-4-[4-(4-benzoylamino-phenoxy)-6-methoxy-quinolin-7-yloxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 35 ℃; for 20h; Product distribution / selectivity;

Reference yield: 46.0%

: 914200-90-1
N-[4-(7-hydroxy-6-methoxy-quinolin-4-yloxy)-phenyl]-benzamide

: 914382-64-2
(S)-2-tert-butoxycarbonylamino-4-hydroxy-butyric acid cyclopentyl ester

: 914382-73-3
(S)-4-[4-(4-benzoylamino-phenoxy)-6-methoxy-quinolin-7-yloxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; at 0 - 20 ℃; for 16h;

Reference yield:

: 15457-50-8
p-benzoylaminophenol

: 914382-73-3
(S)-4-[4-(4-benzoylamino-phenoxy)-6-methoxy-quinolin-7-yloxy]-2-tert-butoxycarbonylamino-butyric acid cyclopentyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 7 h / 145 °C

2: ethanol; cyclohexene / 10 % Pd(OH)2/C / 18 h / Heating / reflux

3: potassium carbonate / N,N-dimethyl-formamide / 20 h / 35 °C

With ethanol; potassium carbonate; cyclohexene; 10 % Pd(OH)2/C; In N,N-dimethyl-formamide;