(2R)-1-((2S,4R)-4-hydroxy-1-{3,3,3-tris(4-fluorophenyl)propanoyl}pyrrolidin-2-yl)carbonyl-N-(4-piperidylmethyl)-pyrrolidine-2-carboxamide

Base Information

Chemical Name:(2R)-1-((2S,4R)-4-hydroxy-1-{3,3,3-tris(4-fluorophenyl)propanoyl}pyrrolidin-2-yl)carbonyl-N-(4-piperidylmethyl)-pyrrolidine-2-carboxamide
CAS No.:323182-81-6
Molecular Formula:C₃₇H₄₁F₃N₄O₄
Molecular Weight:662.752
Hs Code.:

Synonyms:(2R)-1-((2S,4R)-4-hydroxy-1-{3,3,3-tris(4-fluorophenyl)propanoyl}pyrrolidin-2-yl)carbonyl-N-(4-piperidylmethyl)-pyrrolidine-2-carboxamide

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Chemical Property of (2R)-1-((2S,4R)-4-hydroxy-1-{3,3,3-tris(4-fluorophenyl)propanoyl}pyrrolidin-2-yl)carbonyl-N-(4-piperidylmethyl)-pyrrolidine-2-carboxamide

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Technology Process of (2R)-1-((2S,4R)-4-hydroxy-1-{3,3,3-tris(4-fluorophenyl)propanoyl}pyrrolidin-2-yl)carbonyl-N-(4-piperidylmethyl)-pyrrolidine-2-carboxamide

There total 13 articles about (2R)-1-((2S,4R)-4-hydroxy-1-{3,3,3-tris(4-fluorophenyl)propanoyl}pyrrolidin-2-yl)carbonyl-N-(4-piperidylmethyl)-pyrrolidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 43041-12-9
methyl (2R)-pyrrolidine-2-carboxylate

: 323182-81-6
(2R)-1-((2S,4R)-4-hydroxy-1-{3,3,3-tris(4-fluorophenyl)propanoyl}pyrrolidin-2-yl)carbonyl-N-(4-piperidylmethyl)-pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: 5.10 g / WSC*HCl; HOBt / CHCl₃ / 22 h / 20 °C

2: H₂ / Pd(OH)2 / CHCl₃ / 6 h / 20 °C

3: 5.17 g / DIEA; WSC*HCl; HOBt / CHCl₃ / 13 h / 20 °C

4: aq. NaOH / methanol / 0.67 h / 20 °C

5: 3.43 g / WSC*HCl; HOBt / CHCl₃ / 22 h / 20 °C

6: TFA / 3 h / 20 °C

With sodium hydroxide; WSC*HCl; hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium dihydroxide; In methanol; chloroform;
DOI:10.1021/jm051205r

Reference yield:

: 6404-31-5
Z-D-proline

: 323182-81-6
(2R)-1-((2S,4R)-4-hydroxy-1-{3,3,3-tris(4-fluorophenyl)propanoyl}pyrrolidin-2-yl)carbonyl-N-(4-piperidylmethyl)-pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: 78 percent / DMAP; WSC*HCl / CHCl₃ / 1 h / 20 °C

2: H₂ / Pd(OH)2 / methanol / 19 h / 20 °C

3: 5.10 g / WSC*HCl; HOBt / CHCl₃ / 22 h / 20 °C

4: H₂ / Pd(OH)2 / CHCl₃ / 6 h / 20 °C

5: 5.17 g / DIEA; WSC*HCl; HOBt / CHCl₃ / 13 h / 20 °C

6: aq. NaOH / methanol / 0.67 h / 20 °C

7: 3.43 g / WSC*HCl; HOBt / CHCl₃ / 22 h / 20 °C

8: TFA / 3 h / 20 °C

With dmap; sodium hydroxide; WSC*HCl; hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium dihydroxide; In methanol; chloroform;
DOI:10.1021/jm051205r

Reference yield:

: 85201-91-8
(2S,4R)-4-tert-butoxy-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

: 323182-81-6
(2R)-1-((2S,4R)-4-hydroxy-1-{3,3,3-tris(4-fluorophenyl)propanoyl}pyrrolidin-2-yl)carbonyl-N-(4-piperidylmethyl)-pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: 5.10 g / WSC*HCl; HOBt / CHCl₃ / 22 h / 20 °C

2: H₂ / Pd(OH)2 / CHCl₃ / 6 h / 20 °C

3: 5.17 g / DIEA; WSC*HCl; HOBt / CHCl₃ / 13 h / 20 °C

4: aq. NaOH / methanol / 0.67 h / 20 °C

5: 3.43 g / WSC*HCl; HOBt / CHCl₃ / 22 h / 20 °C

6: TFA / 3 h / 20 °C

With sodium hydroxide; WSC*HCl; hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium dihydroxide; In methanol; chloroform;
DOI:10.1021/jm051205r