(2R)-1-((2S,4R)-4-tert-butoxy-1-[3,3,3-tris(4-fluorophenyl)propanoyl]pyrrolidin-2-yl)carbonyl-N-[4-(tert-butoxycarbonyl)piperidinylmethyl]pyrrolidine-2-carboxamide

Base Information

Chemical Name:(2R)-1-((2S,4R)-4-tert-butoxy-1-[3,3,3-tris(4-fluorophenyl)propanoyl]pyrrolidin-2-yl)carbonyl-N-[4-(tert-butoxycarbonyl)piperidinylmethyl]pyrrolidine-2-carboxamide
CAS No.:1053691-94-3
Molecular Formula:C₄₆H₅₇F₃N₄O₆
Molecular Weight:818.977
Hs Code.:

(2R)-1-((2S,4R)-4-tert-butoxy-1-[3,3,3-tris(4-fluorophenyl)propanoyl]pyrrolidin-2-yl)carbonyl-N-[4-(tert-butoxycarbonyl)piperidinylmethyl]pyrrolidine-2-carboxamide

Synonyms:(2R)-1-((2S,4R)-4-tert-butoxy-1-[3,3,3-tris(4-fluorophenyl)propanoyl]pyrrolidin-2-yl)carbonyl-N-[4-(tert-butoxycarbonyl)piperidinylmethyl]pyrrolidine-2-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-1-((2S,4R)-4-tert-butoxy-1-[3,3,3-tris(4-fluorophenyl)propanoyl]pyrrolidin-2-yl)carbonyl-N-[4-(tert-butoxycarbonyl)piperidinylmethyl]pyrrolidine-2-carboxamide

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2R)-1-((2S,4R)-4-tert-butoxy-1-[3,3,3-tris(4-fluorophenyl)propanoyl]pyrrolidin-2-yl)carbonyl-N-[4-(tert-butoxycarbonyl)piperidinylmethyl]pyrrolidine-2-carboxamide

There total 11 articles about (2R)-1-((2S,4R)-4-tert-butoxy-1-[3,3,3-tris(4-fluorophenyl)propanoyl]pyrrolidin-2-yl)carbonyl-N-[4-(tert-butoxycarbonyl)piperidinylmethyl]pyrrolidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 43041-12-9
methyl (2R)-pyrrolidine-2-carboxylate

: 1053691-94-3
(2R)-1-((2S,4R)-4-tert-butoxy-1-[3,3,3-tris(4-fluorophenyl)propanoyl]pyrrolidin-2-yl)carbonyl-N-[4-(tert-butoxycarbonyl)piperidinylmethyl]pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 5.10 g / WSC*HCl; HOBt / CHCl₃ / 22 h / 20 °C

2: H₂ / Pd(OH)2 / CHCl₃ / 6 h / 20 °C

3: 5.17 g / DIEA; WSC*HCl; HOBt / CHCl₃ / 13 h / 20 °C

4: aq. NaOH / methanol / 0.67 h / 20 °C

5: 3.43 g / WSC*HCl; HOBt / CHCl₃ / 22 h / 20 °C

With sodium hydroxide; WSC*HCl; hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In methanol; chloroform;
DOI:10.1021/jm051205r

Reference yield:

: 6404-31-5
Z-D-proline

: 1053691-94-3
(2R)-1-((2S,4R)-4-tert-butoxy-1-[3,3,3-tris(4-fluorophenyl)propanoyl]pyrrolidin-2-yl)carbonyl-N-[4-(tert-butoxycarbonyl)piperidinylmethyl]pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: 78 percent / DMAP; WSC*HCl / CHCl₃ / 1 h / 20 °C

2: H₂ / Pd(OH)2 / methanol / 19 h / 20 °C

3: 5.10 g / WSC*HCl; HOBt / CHCl₃ / 22 h / 20 °C

4: H₂ / Pd(OH)2 / CHCl₃ / 6 h / 20 °C

5: 5.17 g / DIEA; WSC*HCl; HOBt / CHCl₃ / 13 h / 20 °C

6: aq. NaOH / methanol / 0.67 h / 20 °C

7: 3.43 g / WSC*HCl; HOBt / CHCl₃ / 22 h / 20 °C

With dmap; sodium hydroxide; WSC*HCl; hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In methanol; chloroform;
DOI:10.1021/jm051205r

Reference yield:

: 85201-91-8
(2S,4R)-4-tert-butoxy-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester

: 1053691-94-3
(2R)-1-((2S,4R)-4-tert-butoxy-1-[3,3,3-tris(4-fluorophenyl)propanoyl]pyrrolidin-2-yl)carbonyl-N-[4-(tert-butoxycarbonyl)piperidinylmethyl]pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 5.10 g / WSC*HCl; HOBt / CHCl₃ / 22 h / 20 °C

2: H₂ / Pd(OH)2 / CHCl₃ / 6 h / 20 °C

3: 5.17 g / DIEA; WSC*HCl; HOBt / CHCl₃ / 13 h / 20 °C

4: aq. NaOH / methanol / 0.67 h / 20 °C

5: 3.43 g / WSC*HCl; HOBt / CHCl₃ / 22 h / 20 °C

With sodium hydroxide; WSC*HCl; hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; palladium dihydroxide; In methanol; chloroform;
DOI:10.1021/jm051205r