6-(9H-Fluoren-9-ylmethoxycarbonylamino)-hexanoic acid (2R,3R,5S)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:6-(9H-Fluoren-9-ylmethoxycarbonylamino)-hexanoic acid (2R,3R,5S)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yl ester
CAS No.:193890-87-8
Molecular Formula:C₆₀H₅₇N₇O₁₁
Molecular Weight:1052.15
Hs Code.:

6-(9H-Fluoren-9-ylmethoxycarbonylamino)-hexanoic acid (2R,3R,5S)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yl ester

Synonyms:6-(9H-Fluoren-9-ylmethoxycarbonylamino)-hexanoic acid (2R,3R,5S)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yl ester

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Chemical Property of 6-(9H-Fluoren-9-ylmethoxycarbonylamino)-hexanoic acid (2R,3R,5S)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yl ester

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Technology Process of 6-(9H-Fluoren-9-ylmethoxycarbonylamino)-hexanoic acid (2R,3R,5S)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yl ester

There total 3 articles about 6-(9H-Fluoren-9-ylmethoxycarbonylamino)-hexanoic acid (2R,3R,5S)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 88574-06-5
6-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}hexanoic acid

: 97776-92-6
3'-deoxy-5'-O-monomethoxytrityl-6-N-[2-(4-nitrophenyl)-ethoxycarbonyl]-adenosine

: 193890-87-8
6-(9H-Fluoren-9-ylmethoxycarbonylamino)-hexanoic acid (2R,3R,5S)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yl ester

Guidance literature:: With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1002/hlca.19970800405

Reference yield:

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 193890-87-8
6-(9H-Fluoren-9-ylmethoxycarbonylamino)-hexanoic acid (2R,3R,5S)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / dimethylformamide; various solvent(s) / 1 h / Ambient temperature

2: 93 percent / EDC, DMAP / CH₂Cl₂ / 3 h / Ambient temperature

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19970800405

Reference yield:

: 60-32-2,93208-38-9
6-aminohexanoic acid

: 193890-87-8
6-(9H-Fluoren-9-ylmethoxycarbonylamino)-hexanoic acid (2R,3R,5S)-5-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-2-{6-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-purin-9-yl}-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / dimethylformamide; various solvent(s) / 1 h / Ambient temperature

2: 93 percent / EDC, DMAP / CH₂Cl₂ / 3 h / Ambient temperature

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19970800405