1-Methyl-3-{[(E)-4-nitro-benzylimino]-p-tolyl-methyl}-1-phenyl-thiourea

Base Information

• Chemical Name: 1-Methyl-3-{[(E)-4-nitro-benzylimino]-p-tolyl-methyl}-1-phenyl-thiourea
• CAS No.: 212254-00-7
• Molecular Formula: C₂₃H₂₂N₄O₂S
• Molecular Weight: 418.519
• Mol file: 212254-00-7.mol

Synonyms:1-Methyl-3-{[(E)-4-nitro-benzylimino]-p-tolyl-methyl}-1-phenyl-thiourea

Chemical Property of 1-Methyl-3-{[(E)-4-nitro-benzylimino]-p-tolyl-methyl}-1-phenyl-thiourea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Methyl-3-{[(E)-4-nitro-benzylimino]-p-tolyl-methyl}-1-phenyl-thiourea

There total 2 articles about 1-Methyl-3-{[(E)-4-nitro-benzylimino]-p-tolyl-methyl}-1-phenyl-thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

N-methylaniline (100-61-8) + p-Methyl-N-(p-nitrobenzyl)benzimidoyl isothiocyanate (212253-99-1) → 1-Methyl-3-{[(E)-4-nitro-benzylimino]-p-tolyl-methyl}-1-phenyl-thiourea (212254-00-7)

Guidance literature:

In acetonitrile;

Reference yield:

N-(4-nitrobenzyl)-4-methylbenzimidoyl chloride (67707-65-7) → 1-Methyl-3-{[(E)-4-nitro-benzylimino]-p-tolyl-methyl}-1-phenyl-thiourea (212254-00-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / acetonitrile / 5 h / 20 - 25 °C

2: 64 percent / acetonitrile

In acetonitrile;

Reference yield: 88.0%

1-Methyl-3-{[(E)-4-nitro-benzylimino]-p-tolyl-methyl}-1-phenyl-thiourea (212254-00-7) → 5-[methyl(phenyl)amino]-2-(4-nitrobenzyl)-3-p-tolyl-1,2,4-thiadiazolium perchlorate (1264264-01-8)

Guidance literature:

1-Methyl-3-{[(E)-4-nitro-benzylimino]-p-tolyl-methyl}-1-phenyl-thiourea; With pyridine; bromine; In dichloromethane;

With sodium perchlorate; In ethanol; water;

DOI:10.1134/S107036321110032X

upstream raw materials:

N-methylaniline

p-Methyl-N-(p-nitrobenzyl)benzimidoyl isothiocyanate

N-(4-nitrobenzyl)-4-methylbenzimidoyl chloride

Downstream raw materials:

5-[methyl(phenyl)amino]-2-(4-nitrobenzyl)-3-p-tolyl-1,2,4-thiadiazolium perchlorate

4-methyl-N-[3-methyl-1,3-benzothiazol-2(3H)-ylidene]-N'-(4-nitrobenzyl)benzenecarboximidamide perchlorate

4-methyl-N-[3-methyl-1,3-benzothiazol-2(3H)-ylidene]-N'-(4-nitrobenzyl)benzenecarboximidamide

9-methyl-3a-(4-nitrophenyl)-2-p-tolyl-3a,9-dihydrobenzo[b]imidazo[4,5-e]-1,4-thiazine