tert-butyl 2-(5-fluoro-2-(5-methyl-6-(methylcarbamoyl)thieno[2,3-d]pyrimidin-4-ylamino)phenoxy)propyl carbamate

Base Information

Chemical Name:tert-butyl 2-(5-fluoro-2-(5-methyl-6-(methylcarbamoyl)thieno[2,3-d]pyrimidin-4-ylamino)phenoxy)propyl carbamate
CAS No.:1332758-52-7
Molecular Formula:C₂₃H₂₈FN₅O₄S
Molecular Weight:489.571
Hs Code.:

Synonyms:tert-butyl 2-(5-fluoro-2-(5-methyl-6-(methylcarbamoyl)thieno[2,3-d]pyrimidin-4-ylamino)phenoxy)propyl carbamate

Suppliers and Price of tert-butyl 2-(5-fluoro-2-(5-methyl-6-(methylcarbamoyl)thieno[2,3-d]pyrimidin-4-ylamino)phenoxy)propyl carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl 2-(5-fluoro-2-(5-methyl-6-(methylcarbamoyl)thieno[2,3-d]pyrimidin-4-ylamino)phenoxy)propyl carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl 2-(5-fluoro-2-(5-methyl-6-(methylcarbamoyl)thieno[2,3-d]pyrimidin-4-ylamino)phenoxy)propyl carbamate

There total 7 articles about tert-butyl 2-(5-fluoro-2-(5-methyl-6-(methylcarbamoyl)thieno[2,3-d]pyrimidin-4-ylamino)phenoxy)propyl carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332758-51-6
4-(2-(1-(tert-butoxycarbonylamino)propan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid

: 1332758-52-7
tert-butyl 2-(5-fluoro-2-(5-methyl-6-(methylcarbamoyl)thieno[2,3-d]pyrimidin-4-ylamino)phenoxy)propyl carbamate

Guidance literature:: 4-(2-(1-(tert-butoxycarbonylamino)propan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

With methylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1332758-51-6
4-(2-(1-(tert-butoxycarbonylamino)propan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid

: 74-89-5
methylamine

: 1332758-52-7
tert-butyl 2-(5-fluoro-2-(5-methyl-6-(methylcarbamoyl)thieno[2,3-d]pyrimidin-4-ylamino)phenoxy)propyl carbamate

Guidance literature:: 4-(2-(1-(tert-butoxycarbonylamino)propan-2-yloxy)-4-fluorophenylamino)-5-methyl-thieno[2,3-d]pyrimidine-6-carboxylic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

methylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 446-36-6
5-fluoro-2-nitrophenol

: 1332758-52-7
tert-butyl 2-(5-fluoro-2-(5-methyl-6-(methylcarbamoyl)thieno[2,3-d]pyrimidin-4-ylamino)phenoxy)propyl carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

2.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C / 2585.81 Torr

3.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 72 h / 100 °C

4.1: sodium hydroxide; methanol / tetrahydrofuran / 20 °C

5.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.08 h / 20 °C

5.2: 20 °C

With methanol; di-tert-butyl-diazodicarboxylate; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; 1.1: Mitsunobu reaction;