5-(chloromethyl)-1-(methoxymethyl)-2-phenylimidazole hydrochloride

Base Information

Chemical Name:5-(chloromethyl)-1-(methoxymethyl)-2-phenylimidazole hydrochloride
CAS No.:119336-40-2
Molecular Formula:C₁₂H₁₃ClN₂O*ClH
Molecular Weight:273.162
Hs Code.:

Synonyms:5-(chloromethyl)-1-(methoxymethyl)-2-phenylimidazole hydrochloride

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Chemical Property of 5-(chloromethyl)-1-(methoxymethyl)-2-phenylimidazole hydrochloride

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Technology Process of 5-(chloromethyl)-1-(methoxymethyl)-2-phenylimidazole hydrochloride

There total 4 articles about 5-(chloromethyl)-1-(methoxymethyl)-2-phenylimidazole hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 119336-39-9
5-(hydroxymethyl)-1-(methoxymethyl)-2-phenylimidazole

: 119336-40-2
5-(chloromethyl)-1-(methoxymethyl)-2-phenylimidazole hydrochloride

Guidance literature:: With thionyl chloride; In chloroform; 1.) RT, overnight, 2.) from 40 to 45 deg C, 30 min;
DOI:10.1021/jo00267a038

Reference yield:

: 670-96-2
2-Phenylimidazole

: 119336-40-2
5-(chloromethyl)-1-(methoxymethyl)-2-phenylimidazole hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi / 1.) THF, hexane, 0 deg C, 30 min, 2.) RT, overnight

2: 1.) sec-BuLi / 1.) THF, hexane, from -40 to -35 deg C, 30 min, 2.) RT, overnight

3: NaBH₄ / methanol / Ambient temperature

4: 100 percent / SOCl₂ / CHCl₃ / 1.) RT, overnight, 2.) from 40 to 45 deg C, 30 min

With sodium tetrahydroborate; n-butyllithium; thionyl chloride; sec.-butyllithium; In methanol; chloroform;
DOI:10.1021/jo00267a038

Reference yield:

: 112655-31-9
1-methoxymethyl-2-phenyl-1H-imidazole

: 119336-40-2
5-(chloromethyl)-1-(methoxymethyl)-2-phenylimidazole hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) sec-BuLi / 1.) THF, hexane, from -40 to -35 deg C, 30 min, 2.) RT, overnight

2: NaBH₄ / methanol / Ambient temperature

3: 100 percent / SOCl₂ / CHCl₃ / 1.) RT, overnight, 2.) from 40 to 45 deg C, 30 min

With sodium tetrahydroborate; thionyl chloride; sec.-butyllithium; In methanol; chloroform;
DOI:10.1021/jo00267a038