ethyl 2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)acetate

Base Information

Chemical Name:ethyl 2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)acetate
CAS No.:1606975-03-4
Molecular Formula:C₂₂H₂₁ClN₄O₂
Molecular Weight:408.887
Hs Code.:

Synonyms:ethyl 2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)acetate

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Chemical Property of ethyl 2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)acetate

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Technology Process of ethyl 2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)acetate

There total 4 articles about ethyl 2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1174229-72-1
ethyl 2-(6-aminopyridin-3-yl)acetate

: 1405676-11-0
4-chloro-2-(3-chlorophenyl)-6-cyclopropylpyrimidine

: 1606975-03-4
ethyl 2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)acetate

Guidance literature:: With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 110 ℃; for 1.25h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 25412-62-8
3-chlorobenzimidamide

: 1606975-03-4
ethyl 2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methylate / ethanol / 20 h / 0 °C / Reflux

2: trichlorophosphate / 1.5 h / 0 - 100 °C

3: caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 1.25 h / 110 °C / Inert atmosphere; Microwave irradiation

With sodium methylate; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trichlorophosphate; In 1,4-dioxane; ethanol;

Reference yield:

: 24922-02-9
Ethyl 3-cyclopropyl-3-oxopropionate

: 1606975-03-4
ethyl 2-(6-((2-(3-chlorophenyl)-6-cyclopropylpyrimidin-4-yl)amino)pyridin-3-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methylate / ethanol / 20 h / 0 °C / Reflux

2: trichlorophosphate / 1.5 h / 0 - 100 °C

3: caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 1.25 h / 110 °C / Inert atmosphere; Microwave irradiation

With sodium methylate; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trichlorophosphate; In 1,4-dioxane; ethanol;