1-[2(R)-[1(R)-(benzyloxycarbamoyl)-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-3-cyclopentylpropionyl]piperidine

Base Information

Chemical Name:1-[2(R)-[1(R)-(benzyloxycarbamoyl)-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-3-cyclopentylpropionyl]piperidine
CAS No.:204637-85-4
Molecular Formula:C₂₉H₄₂N₄O₅
Molecular Weight:526.676
Hs Code.:

Synonyms:1-[2(R)-[1(R)-(benzyloxycarbamoyl)-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-3-cyclopentylpropionyl]piperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[2(R)-[1(R)-(benzyloxycarbamoyl)-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-3-cyclopentylpropionyl]piperidine

Chemical Property:

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Technology Process of 1-[2(R)-[1(R)-(benzyloxycarbamoyl)-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-3-cyclopentylpropionyl]piperidine

There total 17 articles about 1-[2(R)-[1(R)-(benzyloxycarbamoyl)-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-3-cyclopentylpropionyl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 174265-77-1
1-[2(R)-[1(R)-carboxy-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-3-cyclopentylpropionyl]piperidine

: 204637-85-4
1-[2(R)-[1(R)-(benzyloxycarbamoyl)-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-3-cyclopentylpropionyl]piperidine

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; at 0 - 22 ℃; for 8h;
DOI:10.1016/S0960-894X(97)10179-2

Reference yield:

: 223433-54-3
1-[2(R)-[1(R)-(methoxycarbonyl)-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-3-cyclopentylpropionyl]-piperidine

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 204637-85-4
1-[2(R)-[1(R)-(benzyloxycarbamoyl)-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-3-cyclopentylpropionyl]piperidine

Guidance literature:: With ammonium chloride; isopropylmagnesium chloride; In tetrahydrofuran;

Reference yield:

: 204637-83-2
(R)-3-Benzyloxycarbonyl-3-tert-butoxycarbonyl-2-cyclopentylmethyl-4-(3,4,4-trimethyl-2,5-dioxo-imidazolidin-1-yl)-butyric acid benzyl ester

: 204637-85-4
1-[2(R)-[1(R)-(benzyloxycarbamoyl)-2-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)ethyl]-3-cyclopentylpropionyl]piperidine

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd/C

2: N-methymorpholine, NEt₃ / dioxane / Heating

3: EDAC, HOBT

4: CF₃SO₂OSiMe₃, NEt₃ / dioxane / Heating

5: EDAC, HOBT

With 4-methyl-morpholine; trimethylsilyl trifluoromethanesulfonate; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In 1,4-dioxane;
DOI:10.1016/S0960-894X(97)00416-2