204637-83-2Relevant academic research and scientific papers
Alkylation of succinates: Synthesis of Ro 32-3555
McClure, Kim F.,Axt, Matthew Z.
, p. 143 - 146 (2007/10/03)
A short synthesis, based on a succinate acylation-alkylation-decarboxylation approach, of the clinical compound Ro 32-3555 is reported. The nature of the selectivity in the mono-alkylation of succinates was examined under varying enolization conditions and in the presence of chaotropic additives.
Design and synthesis of the cartilage protective agent (CPA, Ro32-3555)
Broadhurst,Brown,Lawton,Ballantyne,Borkakoti,Bottomley,Cooper,Eatherton,Kilford,Malsher,Nixon,Lewis,Sutton,Johnson
, p. 2299 - 2302 (2007/10/03)
A novel series of MMP inhibitors has been identified. The compounds are potent selective inhibitors of collagenase with good solubility and oral bioavailability. One compound, designated Ro32-3555, has been selected for development as a cartilage protective agent for use in the treatment of rheumatoid- and osteoarthritis.
