methyl 2-[1-[[4-[2-(4-chlorophenyl)ethylcarbamoyl]phenyl]methyl]isoquinolin-4-yl]acetate

Base Information

Chemical Name:methyl 2-[1-[[4-[2-(4-chlorophenyl)ethylcarbamoyl]phenyl]methyl]isoquinolin-4-yl]acetate
CAS No.:1233249-94-9
Molecular Formula:C₂₈H₂₅ClN₂O₃
Molecular Weight:472.971
Hs Code.:

Synonyms:methyl 2-[1-[[4-[2-(4-chlorophenyl)ethylcarbamoyl]phenyl]methyl]isoquinolin-4-yl]acetate

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Chemical Property of methyl 2-[1-[[4-[2-(4-chlorophenyl)ethylcarbamoyl]phenyl]methyl]isoquinolin-4-yl]acetate

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Technology Process of methyl 2-[1-[[4-[2-(4-chlorophenyl)ethylcarbamoyl]phenyl]methyl]isoquinolin-4-yl]acetate

There total 12 articles about methyl 2-[1-[[4-[2-(4-chlorophenyl)ethylcarbamoyl]phenyl]methyl]isoquinolin-4-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₁₆ClNO₃

: 156-41-2
4-chlorophenylethylamine

: 1233249-94-9
methyl 2-[1-[[4-[2-(4-chlorophenyl)ethylcarbamoyl]phenyl]methyl]isoquinolin-4-yl]acetate

Guidance literature:: With pyridine; In chloroform; at 0 ℃; for 1h;
DOI:10.1248/cpb.c13-00980

Reference yield:

: 1233249-93-8
4-[[4-(2-methoxy-2-oxoethyl)isoquinolin-1-yl]methyl]benzoic acid

: 156-41-2
4-chlorophenylethylamine

: 1233249-94-9
methyl 2-[1-[[4-[2-(4-chlorophenyl)ethylcarbamoyl]phenyl]methyl]isoquinolin-4-yl]acetate

Guidance literature:: 4-[[4-(2-methoxy-2-oxoethyl)isoquinolin-1-yl]methyl]benzoic acid; With oxalyl dichloride; In chloroform; N,N-dimethyl-formamide; for 1h; Cooling with ice;

4-chlorophenylethylamine; With pyridine; In chloroform; for 1h; Cooling with ice;

Reference yield:

: 1233249-89-2
tributyl-[[4-[(2-methylpropan-2-yl)oxycarbonyl]phenyl]methyl]phosphanium bromide

: 1233249-94-9
methyl 2-[1-[[4-[2-(4-chlorophenyl)ethylcarbamoyl]phenyl]methyl]isoquinolin-4-yl]acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 2 h / -30 - 50 °C

1.2: 2 h / 60 °C

1.3: pH 5

2.1: sodium hydroxide; water / tetrahydrofuran / 2.5 h / 50 °C

2.2: pH 5

3.1: oxalyl dichloride / N,N-dimethyl-formamide; chloroform / 1.17 h / Cooling with ice

3.2: 3 h / Cooling with ice

4.1: trifluoroacetic acid / chloroform / 4 h / 20 °C / Cooling with ice

4.2: pH 5 / Cooling with ice

5.1: oxalyl dichloride / N,N-dimethyl-formamide; chloroform / 1 h / Cooling with ice

5.2: 1 h / Cooling with ice

With oxalyl dichloride; water; sodium hexamethyldisilazane; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;