(R)-N-((1R,2R)-2-(tert-butyldimethylsilyloxy)-2-(3-chlorophenyl)-1-(1-(phenylsulfonyl)-1H-indol-2-yl)ethyl)-2-methylpropane-2-sulfinamide

Base Information

Chemical Name:(R)-N-((1R,2R)-2-(tert-butyldimethylsilyloxy)-2-(3-chlorophenyl)-1-(1-(phenylsulfonyl)-1H-indol-2-yl)ethyl)-2-methylpropane-2-sulfinamide
CAS No.:1429383-31-2
Molecular Formula:C₃₂H₄₁ClN₂O₄S₂Si
Molecular Weight:645.359
Hs Code.:

Synonyms:(R)-N-((1R,2R)-2-(tert-butyldimethylsilyloxy)-2-(3-chlorophenyl)-1-(1-(phenylsulfonyl)-1H-indol-2-yl)ethyl)-2-methylpropane-2-sulfinamide

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Chemical Property of (R)-N-((1R,2R)-2-(tert-butyldimethylsilyloxy)-2-(3-chlorophenyl)-1-(1-(phenylsulfonyl)-1H-indol-2-yl)ethyl)-2-methylpropane-2-sulfinamide

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Technology Process of (R)-N-((1R,2R)-2-(tert-butyldimethylsilyloxy)-2-(3-chlorophenyl)-1-(1-(phenylsulfonyl)-1H-indol-2-yl)ethyl)-2-methylpropane-2-sulfinamide

There total 7 articles about (R)-N-((1R,2R)-2-(tert-butyldimethylsilyloxy)-2-(3-chlorophenyl)-1-(1-(phenylsulfonyl)-1H-indol-2-yl)ethyl)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40899-71-6
1-benzenesulfonylindole

: 1429383-30-1
(R)-N-((R)-2-(tert-butyldimethylsilyloxy)-2-(3-chlorophenyl)ethylidene)-2-methylpropane-2-sulfinamide

: 1429383-31-2
(R)-N-((1R,2R)-2-(tert-butyldimethylsilyloxy)-2-(3-chlorophenyl)-1-(1-(phenylsulfonyl)-1H-indol-2-yl)ethyl)-2-methylpropane-2-sulfinamide

Guidance literature:: 1-benzenesulfonylindole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 0 ℃; for 1.5h; Inert atmosphere;

(R)-N-((R)-2-(tert-butyldimethylsilyloxy)-2-(3-chlorophenyl)ethylidene)-2-methylpropane-2-sulfinamide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 14h; Inert atmosphere;

Reference yield:

: 120-72-9
indole

: 1429383-31-2
(R)-N-((1R,2R)-2-(tert-butyldimethylsilyloxy)-2-(3-chlorophenyl)-1-(1-(phenylsulfonyl)-1H-indol-2-yl)ethyl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1.33 h / 0 °C / Inert atmosphere

1.2: 16 h / 0 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -78 - 0 °C / Inert atmosphere

2.2: 14 h / -78 - 20 °C / Inert atmosphere

With n-butyllithium; sodium hydride; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 153294-01-0
methyl (2R)-{[tert-butyl(dimethyl)silyl]oxy}(3-chlorophenyl)ethanoate

: 1429383-31-2
(R)-N-((1R,2R)-2-(tert-butyldimethylsilyloxy)-2-(3-chlorophenyl)-1-(1-(phenylsulfonyl)-1H-indol-2-yl)ethyl)-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / diethyl ether; toluene / 1 h / -78 °C / Inert atmosphere

2.1: copper(II) sulfate / dichloromethane / 68 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -78 - 0 °C / Inert atmosphere

3.2: 14 h / -78 - 20 °C / Inert atmosphere

With n-butyllithium; diisobutylaluminium hydride; copper(II) sulfate; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; toluene;