suciinimidyl 3-(4-hydroxyphenyl)-2-methylpropanoate

Base Information

• Chemical Name: suciinimidyl 3-(4-hydroxyphenyl)-2-methylpropanoate
• CAS No.: 115060-17-8
• Molecular Formula: C₁₄H₁₅NO₅
• Molecular Weight: 277.277
• Mol file: 115060-17-8.mol

Synonyms:suciinimidyl 3-(4-hydroxyphenyl)-2-methylpropanoate

Chemical Property of suciinimidyl 3-(4-hydroxyphenyl)-2-methylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of suciinimidyl 3-(4-hydroxyphenyl)-2-methylpropanoate

There total 3 articles about suciinimidyl 3-(4-hydroxyphenyl)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + rac-3-(4-hydroxyphenyl)-2-methylpropanoic acid (35456-48-5) → suciinimidyl 3-(4-hydroxyphenyl)-2-methylpropanoate (115060-17-8)

Guidance literature:

With dicyclohexyl-carbodiimide; In ethyl acetate; Ambient temperature;

DOI:10.1248/cpb.36.959

Reference yield:

3-(4-hydroxyphenyl)-2-methylpropionitrile (115044-08-1) → suciinimidyl 3-(4-hydroxyphenyl)-2-methylpropanoate (115060-17-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 79.2 percent / hydrochloric acid, H₂O / 3 h / Heating

2: 68 percent / dicyclohexylcarbodiimide / ethyl acetate / Ambient temperature

With hydrogenchloride; water; dicyclohexyl-carbodiimide; In ethyl acetate;

DOI:10.1248/cpb.36.959

Reference yield:

phenol (108-95-2,27073-41-2) → suciinimidyl 3-(4-hydroxyphenyl)-2-methylpropanoate (115060-17-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 19.9 percent / aluminum chloride, HCl gas / 2.5 h / 60 - 70 °C

2: 79.2 percent / hydrochloric acid, H₂O / 3 h / Heating

3: 68 percent / dicyclohexylcarbodiimide / ethyl acetate / Ambient temperature

With hydrogenchloride; aluminium trichloride; water; dicyclohexyl-carbodiimide; In ethyl acetate;

DOI:10.1248/cpb.36.959

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

rac-3-(4-hydroxyphenyl)-2-methylpropanoic acid

3-(4-hydroxyphenyl)-2-methylpropionitrile

phenol

Downstream raw materials:

3-(4-hydroxyphenyl)-2-methylpropanoyl-Nle-Gly-Trp-Met-Asp-Phe-NH₂

3-(4-hydroxyphenyl)-2-methylpropanoyl-Met-Gly-Trp-Met-Asp-Phe-NH₂