214360-60-8Relevant articles and documents
Synthesis of fluorescent D-amino acids with 4-acetamidobiphenyl and 4-N,N-dimethylamino-1,8-naphthalimido containing side chains
Maity, Jyotirmoy,Honcharenko, Dmytro,Str?mberg, Roger
, p. 4780 - 4783 (2015)
We report the synthesis and fluorescence properties of two aromatic D-amino acids. The key step for the synthesis of (R)-2-amino-3-(4′-acetamido-[1,1′-biphenyl]-4-yl)propanoic acid was a Suzuki cross-coupling reaction between the pinacol diester of N-acetylphenylboronic acid and Fmoc-D-p-bromo-phenylalanine. The second amino acid, (R)-2-amino-4-(4′-N,N-dimethylamino-1,8-naphthalimido)butanoic acid [(R)-2-amino-4-DMNA-butanoic acid], was synthesized in four steps from 4-bromo-1,8-naphthalic anhydride. The amino acids were prepared in a form that could be readily incorporated into a peptide sequence by solid phase peptide synthesis using the Fmoc-strategy. Evaluation of the fluorescence properties of the biphenyl amino acid showed a maximum emission at 384 nm (excitation at 295 nm) while the naphthalimido amino acid showed a maximum emission at 545 nm (excitation at 450 nm).
Light- and Manganese-Initiated Borylation of Aryl Diazonium Salts: Mechanistic Insight on the Ultrafast Time-Scale Revealed by Time-Resolved Spectroscopic Analysis
Firth, James D.,Hammarback, L. Anders,Burden, Thomas J.,Eastwood, Jonathan B.,Donald, James R.,Horbaczewskyj, Chris S.,McRobie, Matthew T.,Tramaseur, Adam,Clark, Ian P.,Towrie, Michael,Robinson, Alan,Krieger, Jean-Philippe,Lynam, Jason M.,Fairlamb, Ian J. S.
supporting information, p. 3979 - 3985 (2021/02/03)
Manganese-mediated borylation of aryl/heteroaryl diazonium salts emerges as a general and versatile synthetic methodology for the synthesis of the corresponding boronate esters. The reaction proved an ideal testing ground for delineating the Mn species responsible for the photochemical reaction processes, that is, involving either Mn radical or Mn cationic species, which is dependent on the presence of a suitably strong oxidant. Our findings are important for a plethora of processes employing Mn-containing carbonyl species as initiators and/or catalysts, which have considerable potential in synthetic applications.
CANCER TREATMENTS TARGETING CANCER STEM CELLS
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Paragraph 0331; 0677-0679, (2019/11/19)
Disclosed are compounds, methods, compositions, and kits that allow for treating cancer by, e.g., targeting cancer stem cells. In some embodiments, the cancer is colorectal cancer, gastric cancer, gastrointestinal stromal tumor, ovarian cancer, lung cancer, breast cancer, pancreatic cancer, prostate cancer, testicular cancer, or lymphoma. In some embodiments, the cancer is liver cancer, endometrial cancer, leukemia, or multiple myeloma. The compounds utilized in the disclosure are of Formula (0), (O'), and (I):
