Technology Process of C30H24F6N4O4
There total 3 articles about C30H24F6N4O4 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-trifluoromethylbenzoic acid;
With
1,1'-carbonyldiimidazole;
In
N,N-dimethyl-formamide;
N-[4-(1,2,3,6-tetrahydro-pyridin-4-yl)-3-trifluoromethylbenzoyl]-N?'-(carbobenzyloxy)guanidine;
With
N-ethyl-N,N-diisopropylamine;
at 20 ℃;
DOI:10.1021/jm300601d
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sulfuric acid / 80 °C
2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 4 h / 140 °C
3.1: potassium carbonate / methanol; water / 2 h / 60 °C
3.2: pH 4
4.1: 2-chloro-1-methyl-pyridinium iodide / 1-methyl-pyrrolidin-2-one / 1 h / 20 - 50 °C
4.2: 20 °C
5.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 2 h
6.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide
6.2: 20 °C
With
hydrogenchloride; tetrakis(triphenylphosphine) palladium(0); sulfuric acid; 2-chloro-1-methyl-pyridinium iodide; potassium carbonate; 1,1'-carbonyldiimidazole;
In
1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; N,N-dimethyl-formamide;
2.1: |Suzuki Coupling;
DOI:10.1021/jm300601d
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 2 h
2.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide
2.2: 20 °C
With
hydrogenchloride; 1,1'-carbonyldiimidazole;
In
1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm300601d
