2-(2-{4-[2-(2-hydroxyethoxy)ethoxymethyl]benzyloxy}ethoxy)ethanol

Base Information

• Chemical Name: 2-(2-{4-[2-(2-hydroxyethoxy)ethoxymethyl]benzyloxy}ethoxy)ethanol
• CAS No.: 183151-57-7
• Molecular Formula: C₁₆H₂₆O₆
• Molecular Weight: 314.379
• Mol file: 183151-57-7.mol

Synonyms:2-(2-{4-[2-(2-hydroxyethoxy)ethoxymethyl]benzyloxy}ethoxy)ethanol

Chemical Property of 2-(2-{4-[2-(2-hydroxyethoxy)ethoxymethyl]benzyloxy}ethoxy)ethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-{4-[2-(2-hydroxyethoxy)ethoxymethyl]benzyloxy}ethoxy)ethanol

There total 1 articles about 2-(2-{4-[2-(2-hydroxyethoxy)ethoxymethyl]benzyloxy}ethoxy)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1,4-bis(bromomethyl)benzene (623-24-5) + diethylene glycol (111-46-6) → 2-(2-{4-[2-(2-hydroxyethoxy)ethoxymethyl]benzyloxy}ethoxy)ethanol (183151-57-7)

Guidance literature:

diethylene glycol; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h;

1,4-bis(bromomethyl)benzene; In tetrahydrofuran; for 16h; Reflux;

DOI:10.1039/c3ob42418a

Reference yield: 76.0%

p-toluenesulfonyl chloride (98-59-9) + 2-(2-{4-[2-(2-hydroxyethoxy)ethoxymethyl]benzyloxy}ethoxy)ethanol (183151-57-7) → 2-(2-{4-[2-(2-tosyloxyethoxy)ethoxymethyl]benzyloxy}ethoxy)ethyl toluene-4-sulfonate (881890-43-3)

Guidance literature:

With sodium hydroxide; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1002/ejoc.200500421

Reference yield:

2-(2-{4-[2-(2-hydroxyethoxy)ethoxymethyl]benzyloxy}ethoxy)ethanol (183151-57-7) → C37H51N3O3*C23H31NO6 (1599475-95-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / tetrahydrofuran / 72 h / Reflux

2: sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate / dichloromethane

With sodium hydride; sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; In tetrahydrofuran; dichloromethane;

DOI:10.1039/c3ob42418a

upstream raw materials:

1,4-bis(bromomethyl)benzene

diethylene glycol

Downstream raw materials:

2-(2-{4-[2-(2-tosyloxyethoxy)ethoxymethyl]benzyloxy}ethoxy)ethyl toluene-4-sulfonate

4-{2-[2-(4-{2-[2-(2,6-dimethyl-4-tritylphenoxy)ethoxy]ethoxymethyl}benzyloxy)ethoxy]ethoxy}but-2-yn-1-ol

2-{2-[2-(4-{2-[2-(4-bromobut-2-ynyloxy)ethoxy]ethoxymethyl}benzyloxy)ethoxy]ethoxy}-1,3-dimethyl-5-tritylbenzol

2-[2-(4-{2-[2-(2,6-dimethyl-4-tritylphenoxy)ethoxy]ethoxymethyl}benzyloxy)ethoxy]ethyl toluene-4-sulfonate