4-(3,4-dichloro-benzyl)-4-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-(3,4-dichloro-benzyl)-4-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 1010190-24-5
• Molecular Formula: C₁₈H₂₅Cl₂NO₃
• Molecular Weight: 374.307
• Mol file: 1010190-24-5.mol

Synonyms:4-(3,4-dichloro-benzyl)-4-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of 4-(3,4-dichloro-benzyl)-4-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3,4-dichloro-benzyl)-4-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester

There total 4 articles about 4-(3,4-dichloro-benzyl)-4-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

4-(3,4-dichloro-benzyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester (1010190-21-2) → 4-(3,4-dichloro-benzyl)-4-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester (1010190-24-5)

Guidance literature:

4-(3,4-dichloro-benzyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester; With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 0 ℃; for 1h;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether;

Reference yield:

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate (142851-03-4) → 4-(3,4-dichloro-benzyl)-4-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester (1010190-24-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.67 h / -78 - -30 °C

1.2: -78 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

With lithium aluminium tetrahydride; lithium diisopropyl amide; In tetrahydrofuran;

DOI:10.1038/aps.2016.124

Reference yield:

4-carbethoxypiperidine (1126-09-6) → 4-(3,4-dichloro-benzyl)-4-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester (1010190-24-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dichloromethane / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.67 h / -78 - -30 °C

2.2: -78 - 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 °C

With lithium aluminium tetrahydride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;

DOI:10.1038/aps.2016.124

upstream raw materials:

4-(3,4-dichloro-benzyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

4-carbethoxypiperidine

di-tert-butyl dicarbonate

Downstream raw materials:

C₂₄H₂₉Cl₂NO₃