4-(3,4-dichloro-benzyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

Base Information

Chemical Name:4-(3,4-dichloro-benzyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester
CAS No.:1010190-21-2
Molecular Formula:C₂₀H₂₇Cl₂NO₄
Molecular Weight:416.345
Hs Code.:

Synonyms:4-(3,4-dichloro-benzyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

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Chemical Property of 4-(3,4-dichloro-benzyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

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Technology Process of 4-(3,4-dichloro-benzyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

There total 4 articles about 4-(3,4-dichloro-benzyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 18880-04-1
3,4-dichlorobenzyl bromide

: 1010190-21-2
4-(3,4-dichloro-benzyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

Guidance literature:: 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate; With lithium diisopropyl amide; In tetrahydrofuran; hexanes; at -78 - -30 ℃; for 0.5h;

3,4-dichlorobenzyl bromide; In tetrahydrofuran; hexanes; at -78 - 20 ℃;

Reference yield:

: 142851-03-4
1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate

: 18880-04-1
3,4-dichlorobenzyl bromide

: 1010190-21-2
4-(3,4-dichloro-benzyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

Guidance literature:: 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - -30 ℃; for 0.666667h;

3,4-dichlorobenzyl bromide; In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1038/aps.2016.124

Reference yield:

: 1126-09-6
4-carbethoxypiperidine

: 1010190-21-2
4-(3,4-dichloro-benzyl)-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 0 - 20 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.67 h / -78 - -30 °C

2.2: -78 - 20 °C

With lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1038/aps.2016.124